Delayed non-myeloablative irradiation to induce long-term allograft acceptance in a large animal lung transplantation model.
Sign Up to like & getrecommendations! Published in 2020 at "Transplant immunology"
DOI: 10.1016/j.trim.2020.101350
Abstract: We previously induced long-term allograft acceptance in an allogeneic lung transplantation (LTx) model in miniature swine using perioperative non-myeloablative irradiation (IRR) combined with infusion of donor specific alloantigen. In order to improve clinical applicability, we… read more here.
Keywords: irradiation; long term; allograft acceptance; group ... See more keywords
Combinations of anti-GITR antibody and CD28 superagonist induce permanent allograft acceptance by generating type 1 regulatory T cells
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo4413
Abstract: Type 1 regulatory T (Tr1) cells represent a subset of IL-10–producing CD4+Foxp3− T cells and play key roles in promoting transplant tolerance. However, no effective pharmacological approaches have been able to induce Tr1 cells in… read more here.
Keywords: tr1; permanent allograft; allograft acceptance; cd28 superagonist ... See more keywords