Extracellular vesicle‐bound DNA in urine is indicative of kidney allograft injury
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12268
Abstract: Extracellular vesicle-bound DNA (evDNA) is an understudied extracellular vesicle (EV) cargo, particularly in cancer-unrelated fundamental and biomarker research. Although evDNA has been detected in urine, little is known about its characteristics, localization, and biomarker potential… read more here.
Keywords: dna; kidney; allograft injury; evdna ... See more keywords
A Standardized Protocol for Donor-Derived Cell-Free DNA Quantification in the Diagnosis of Allograft Injury
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Heart and Lung Transplantation"
DOI: 10.1016/j.healun.2021.01.679
Abstract: Purpose There is an increasing interest in the use of donor-derived cfDNA (dd-cfDNA) in transplantation for non-invasive diagnosis of allograft injury. We hereby describe a non-commercial routine procedure for dd-cfDNA detection and quantification using digital… read more here.
Keywords: cfdna; donor derived; donor; quantification ... See more keywords
Circulating cell-free DNA methylation patterns indicate cellular sources of allograft injury after liver transplant
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-60507-9
Abstract: Post-transplant complications reduce allograft and recipient survival. Current approaches for detecting allograft injury non-invasively are limited and do not differentiate between cellular mechanisms. Here, we monitor cellular damages after liver transplants from cell-free DNA (cfDNA)… read more here.
Keywords: free dna; methylation; cell free; allograft injury ... See more keywords
Cell-free DNA in lung transplantation: research tool or clinical workhorse?
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Organ Transplantation"
DOI: 10.1097/mot.0000000000000979
Abstract: Purpose of review Recent evidence indicates that plasma donor-derived cell-free DNA (dd-cfDNA) is a sensitive biomarker for the detection of underlying allograft injury, including rejection and infection. In this review, we will cover the latest… read more here.
Keywords: allograft injury; cell free; cfdna; lung ... See more keywords
Urinary Biomarkers for Kidney Allograft Injury
Sign Up to like & getrecommendations! Published in 2022 at "Transplantation"
DOI: 10.1097/tp.0000000000004017
Abstract: The current standard of serum creatinine and biopsy to monitor allograft health has many limitations. The most significant drawback of the current standard is the lack of sensitivity and specificity to allograft injuries, which are… read more here.
Keywords: allograft injury; kidney allograft; biomarkers kidney; allograft ... See more keywords
Proteomics: Its Promise and Pitfalls in Shaping Precision Medicine in Solid Organ Transplantation.
Sign Up to like & getrecommendations! Published in 2023 at "Transplantation"
DOI: 10.1097/tp.0000000000004539
Abstract: Solid organ transplantation is an established treatment of choice for end-stage organ failure. However, all transplant patients are at risk of developing complications, including allograft rejection and death. Histological analysis of graft biopsy is still… read more here.
Keywords: organ transplantation; data sets; allograft injury; transplantation ... See more keywords
Sustained Molecular Allograft Injury After Episodes of Acute Rejection and Organizing Pneumonia Increases the Risk of Lung Allograft Failure
Sign Up to like & getrecommendations! Published in 2025 at "Transplantation Direct"
DOI: 10.1097/txd.0000000000001828
Abstract: Background. Despite treatment of major risk factors such as acute rejection (AR) and organizing pneumonia (OP) in lung transplant recipients, chronic lung allograft dysfunction (CLAD) still develops at high rates, suggesting that traditional methods of… read more here.
Keywords: allograft; allograft injury; molecular allograft; lung allograft ... See more keywords
Association of gut microbiota with allograft injury in kidney transplant recipients: a comparative profiling through 16S metagenomics and quantitative PCR.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medical microbiology"
DOI: 10.1099/jmm.0.001934
Abstract: Introduction. The existence of a mutual relationship between gut microbiota and immune homeostasis highlights its importance in the context of kidney transplantation.Gap statement. The translational utility of gut microbiota as a biomarker for allograft injury… read more here.
Keywords: gut microbiota; allograft injury; gut microbial; gut ... See more keywords
Impact of Allograft Injury Time of Onset on the Development of Chronic Lung Allograft Dysfunction After Lung Transplantation
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Transplantation"
DOI: 10.1111/ajt.14066
Abstract: The impact of allograft injury time of onset on the risk of chronic lung allograft dysfunction (CLAD) remains unknown. We hypothesized that episodes of late‐onset (≥6 months) allograft injury would produce an augmented CXCR3/ligand immune… read more here.
Keywords: time onset; allograft injury; injury; lung ... See more keywords
KLF4 Affects Acute Renal Allograft Injury via Binding to MicroRNA-155-5p Promoter to Regulate ERRFI1
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/5845627
Abstract: Kruppel-like factor 4 (KLF4) owns the promising potential in treating kidney injury, which inevitably occurs during renal allograft. Given that, this research targets to unveil KLF4-oriented mechanism from microRNA-155-5p/ERBB receptor feedback inhibitor 1 (miR-155-5p/ERRFI1) axis… read more here.
Keywords: mir 155; renal allograft; allograft injury; acute renal ... See more keywords