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   Articles with "alloimmune thrombocytopenia" as a keyword



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Down syndrome with neonatal alloimmune thrombocytopenia due to anti-HLA A31 and B61 antibodies

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recommendations! Published in 2021 at "International Journal of Hematology"

DOI: 10.1007/s12185-021-03092-z

Abstract: Neonatal alloimmune thrombocytopenia (NAIT) arises from fetomaternal platelet incompatibility that results in transplacental passage of maternal antibodies mostly against fetal human platelet antigens (HPA), whereas NAIT due to anti-human leukocyte antigen (HLA) antibodies is extremely… read more here.

Keywords: alloimmune thrombocytopenia; hla antibodies; hla; neonatal alloimmune ... See more keywords
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Taking a wider view on fetal/neonatal alloimmune thrombocytopenia.

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recommendations! Published in 2017 at "Thrombosis research"

DOI: 10.1016/s0049-3848(17)30078-6

Abstract: In fetal/neonatal alloimmune thrombocytopenia (FNAIT), platelets are destroyed by maternal antibodies directed against fetal/neonate antigens. Thrombocytopenia can be severe and lead to intracranial hemorrhage (ICH) in about 10% of cases. Although three types of antigen… read more here.

Keywords: thrombocytopenia; fetal neonatal; alloimmune thrombocytopenia; neonatal alloimmune ... See more keywords
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IVIG-Associated Maternal Pancytopenia during Treatment for Neonatal Alloimmune Thrombocytopenia

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recommendations! Published in 2017 at "AJP Reports"

DOI: 10.1055/s-0037-1607055

Abstract: Background  Treatment for neonatal alloimmune thrombocytopenia (NAIT) primarily involves maternal administration of intravenous immunoglobulin (IVIG) therapy and prednisone according to protocols based on risk stratification. While IVIG is generally well tolerated, hematologic side effects are… read more here.

Keywords: treatment; pancytopenia; ivig; alloimmune thrombocytopenia ... See more keywords
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Screening for fetal and neonatal alloimmune thrombocytopenia – lessons learned from a Norwegian screening program

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recommendations! Published in 2018 at "Acta Obstetricia et Gynecologica Scandinavica"

DOI: 10.1111/aogs.13320

Abstract: An important issue on human platelet antigen (HPA)-1a screening has recently been addressed in Acta Obstetrica et Gynecologica Scandinavia. Winkelhorst et al. reported that the vast majority of women in the general pregnant population were positive… read more here.

Keywords: fetal neonatal; alloimmune thrombocytopenia; thrombocytopenia lessons; lessons learned ... See more keywords
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Maternal HLA genotyping is not useful for predicting severity of fetal and neonatal alloimmune thrombocytopenia

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recommendations! Published in 2017 at "British Journal of Haematology"

DOI: 10.1111/bjh.14385

Abstract: Lack of reliable laboratory parameters is the main challenge in the management of fetal and neonatal alloimmune thrombocytopenia (FNAIT). Despite the long‐known association between the HLA‐DRB3*01:01 allele and human platelet antigen 1a (HPA‐1a) alloimmunisation, maternal… read more here.

Keywords: fetal neonatal; alloimmune thrombocytopenia; hla; hla genotyping ... See more keywords
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Preliminary mechanism in fetal alloimmune thrombocytopenia associated with anti‐HPA 15b antibodies

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recommendations! Published in 2022 at "Journal of Obstetrics and Gynaecology Research"

DOI: 10.1111/jog.15257

Abstract: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a bleeding disease that can cause fetal hydrops, a rare but life‐threatening condition in which abnormal amounts of fluid accumulate in one or two areas of the fetus's… read more here.

Keywords: hpa 15b; alloimmune thrombocytopenia; 15b antibodies; anti hpa ... See more keywords
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HLA‐DRB3*01:01 is a predictor of immunization against human platelet antigen‐1a but not of the severity of fetal and neonatal alloimmune thrombocytopenia

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recommendations! Published in 2017 at "Transfusion"

DOI: 10.1111/trf.13950

Abstract: Most cases of fetal and neonatal alloimmune thrombocytopenia (FNAIT) are caused by maternal alloantibodies against human platelet antigen‐1a (HPA‐1a). Alloimmunization mainly occurs in HPA‐1a–negative mothers who are carriers of the HLA‐DRB3*01:01 allele. Recently, it has… read more here.

Keywords: fetal neonatal; alloimmune thrombocytopenia; hla; neonatal alloimmune ... See more keywords

Transplantation-mediated alloimmune thrombocytopenia successfully treated by retransplantation

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recommendations! Published in 2021 at "Lupus"

DOI: 10.1177/0961203320983450

Abstract: Introduction Transplantation-mediated alloimmune thrombocytopenia (TMAT) is a rare complication affecting the recipient of an organ from a donor with immune thrombocytopenia (ITP). Methods We present a case of TMAT following liver transplantation successfully treated by… read more here.

Keywords: thrombocytopenia; retransplantation; transplantation mediated; alloimmune thrombocytopenia ... See more keywords
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Prophylactic administration of HPA-1a-specific antibodies prevents fetal/neonatal alloimmune thrombocytopenia in mice.

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recommendations! Published in 2022 at "Blood"

DOI: 10.1182/blood.2022015666

Abstract: Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a life-threatening bleeding disorder caused by maternal alloantibodies directed against paternally inherited human platelet alloantigens (HPAs) present on the surface of fetal and neonatal platelets. There are currently no approved… read more here.

Keywords: hpa specific; specific antibodies; alloimmune thrombocytopenia; hpa ... See more keywords
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Neonatal alloimmune thrombocytopenia caused by anti-HPA antibodies in pregnant Chinese women: a study protocol for a multicentre, prospective cohort trial

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recommendations! Published in 2017 at "BMC Pregnancy and Childbirth"

DOI: 10.1186/s12884-017-1453-y

Abstract: BackgroundNeonatal alloimmune thrombocytopenia (NAIT), caused by maternal antibodies raised against alloantigens carried on foetal platelets, is a very common haematological abnormality in newborns worldwide. However, baseline data on NAIT in China are lacking. Therefore, this… read more here.

Keywords: hpa antibody; anti hpa; alloimmune thrombocytopenia; hpa ... See more keywords