Alloimmunization and autoimmunization in adult transfusion-dependent thalassemia patients: a report from a comprehensive center in Israel
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DOI: 10.1007/s00277-020-04104-4
Abstract: Patients with beta thalassemia major (TM) are transfusion-dependent (TD) since early childhood and for life. Development of alloantibodies and autoantibodies against red blood cell (RBC) antigens is increasingly recognized as a significant transfusion hazard, especially… read more here.
Keywords: alloimmunization; comprehensive center; transfusion dependent; transfusion ... See more keywords
Transplant nephrectomy after graft failure: is it so risky? Impact on morbidity, mortality and alloimmunization
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DOI: 10.1007/s11255-018-1960-4
Abstract: PurposeTo determine the impact of transplant nephrectomy on morbidity and mortality and HLA immunization.MethodsAll patients who underwent transplant nephrectomy in our centre between 2000 and 2016 were included in this study. A total of 2822… read more here.
Keywords: impact; alloimmunization; transplant nephrectomy; morbidity mortality ... See more keywords
Successful outcome of pregnancy post‐allogeneic stem cell transplant despite severe RH1 alloimmunization: A case report
Sign Up to like & getrecommendations! Published in 2023 at "British Journal of Haematology"
DOI: 10.1111/bjh.18741
Abstract: Rhesus D antigen (RH1)negative women, when exposed to RH1positive red blood cells (RBC), are at risk of developing antiRH1 antibodies. If their offspring are RH1positive, there is a risk of haemolytic disease of the fetus… read more here.
Keywords: alloimmunization; pregnancy; antibody; rh1 ... See more keywords
The prevalence of HPA‐1a alloimmunization and the potential risk of FNAIT depend on both the DRB3*01:01 allele and associated DR‐DQ haplotypes
Sign Up to like & getrecommendations! Published in 2020 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12890
Abstract: Alloimmunization against human platelet antigen (HPA)‐1a during pregnancy can cause foetal/neonatal alloimmune thrombocytopenia (FNAIT) and severe bleeding in the foetus or newborn and likely depends on several factors. HPA‐1a alloimmunization is associated with DRB3*01:01, which… read more here.
Keywords: prevalence hpa; alloimmunization; hpa alloimmunization; hpa ... See more keywords
Medical and economic implications of strategies to prevent alloimmunization in sickle cell disease
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DOI: 10.1111/trf.14212
Abstract: The pathogenesis of alloimmunization is not well understood, and initiatives that aim to reduce the incidence of alloimmunization are generally expensive and either ineffective or unproven. In this review, we summarize the current medical literature… read more here.
Keywords: alloimmunization; alloimmunization sickle; prevent alloimmunization; cell disease ... See more keywords
Ultraviolet light‐based pathogen inactivation and alloimmunization after platelet transfusion: results from a randomized trial
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DOI: 10.1111/trf.14534
Abstract: The current study explored whether pathogen‐reduction treatment of platelet components before transfusion would decrease the risk of alloimmunization. read more here.
Keywords: pathogen; alloimmunization; transfusion; light based ... See more keywords
Anti‐D alloimmunization in Rh(D) negative adults with severe traumatic injury
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DOI: 10.1111/trf.16493
Abstract: Widely varying rates of alloimmunization associated with transfusing uncrossmatched RBC products to trauma patients as part of hemostatic resuscitation have been reported. We characterized the rates of RBC alloimmunization in our severely injured Rh(D) negative… read more here.
Keywords: negative adults; alloimmunization; anti alloimmunization; severe traumatic ... See more keywords
Clodronate inhibits alloimmunization against distinct red blood cell alloantigens in mice.
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DOI: 10.1111/trf.16872
Abstract: BACKGROUND Alloimmunization can be a significant barrier to red blood cell (RBC) transfusion. While alloantigen matching protocols hold promise in reducing alloantibody formation, transfusion-dependent patients can still experience RBC alloimmunization and associated complications even when… read more here.
Keywords: transfusion; formation; alloimmunization; clodronate ... See more keywords
Storage differentially impacts alloimmunization to distinct red cell antigens following transfusion in mice
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DOI: 10.1111/trf.17251
Abstract: The impact of blood storage on red blood cell (RBC) alloimmunization remains controversial, with some studies suggesting enhancement of RBC‐induced alloantibody production and others failing to observe any impact of storage on alloantibody formation. Since… read more here.
Keywords: cell; differentially impacts; transfusion; storage differentially ... See more keywords
Rh alloimmunization following transfusion of one apheresis platelet unit
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DOI: 10.1111/trf.17258
Abstract: Various authors have reported on the potential for Rh alloimmunization following transfusion of RhD-positive platelets to RhD-negative recipients. The risk of alloimmunization is greater for recipients of whole blood-derived (WBD) pooled platelets compared to apheresis… read more here.
Keywords: platelet; apheresis; unit; patient ... See more keywords
Timing of RhD‐positive red blood cell administration is associated with D‐alloimmunization in injured patients
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DOI: 10.1111/trf.17330
Abstract: The D‐alloimmunization rate in trauma patients does not appear to depend on the number of RhD‐positive units transfused. The effect of the timing and pattern of RhD‐positive transfusions has not been evaluated. read more here.
Keywords: timing rhd; red blood; rhd positive; blood cell ... See more keywords