Allopregnanolone Effects on Inhibition in Hippocampal Parvalbumin Interneurons
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DOI: 10.1523/eneuro.0392-22.2023
Abstract: Abstract Allopregnanolone (AlloP) is a neurosteroid that potentiates ionotropic GABAergic (GABAA) inhibition and is approved for treating postpartum depression in women. Although the antidepressant mechanism of AlloP is largely unknown, it could involve selective action… read more here.
Keywords: inhibition; allopregnanolone effects; effects inhibition; parvalbumin interneurons ... See more keywords
The Enantiomer of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.855779
Abstract: In an ex vivo rat ocular hypertension (OHT) model, the neurosteroid allopregnanolone (AlloP) exerts neuroprotective effects via enhancement of both GABAA receptors and autophagy. We now examine whether its enantiomer (ent-AlloP), which is largely inactive… read more here.
Keywords: vivo; pressure; allop; allopregnanolone ... See more keywords