GR3027 reversal of neurosteroid-induced, GABA-A receptor-mediated inhibition of human brain function: an allopregnanolone challenge study
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-4864-1
Abstract: RationaleGR3027 is a novel small molecule GABA-A receptor-modulating steroid antagonist, which in non-clinical studies has shown promise for treatment of human disorders due to allosteric over-activation of GABA-A receptors by neurosteroids, such as allopregnanolone. We… read more here.
Keywords: brain function; gaba receptor; gr3027; allopregnanolone induced ... See more keywords
Increased Superoxide Dismutase 2 by Allopregnanolone Ameliorates ROS-Mediated Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2561-4
Abstract: Excessive production of reactive oxygen species (ROS), along with dysfunction of the antioxidant defense system, such as that involving superoxide dismutase (SOD), may play a major role in neuronal death following status epilepticus (SE). Neurosteroids,… read more here.
Keywords: death; neuronal death; ros mediated; status epilepticus ... See more keywords
Allopregnanolone decreases interictal spiking and fast ripples in an animal model of mesial temporal lobe epilepsy
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DOI: 10.1016/j.neuropharm.2017.04.020
Abstract: Abstract The objective of this study was to characterize the impact of allopregnanolone, a neurosteroid that acts as a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors, on interictal spikes and high‐frequency oscillations (ripples:… read more here.
Keywords: interictal spikes; mesial temporal; fast ripples; model mesial ... See more keywords
Hemisphere-dependent Changes in mRNA Expression of GABAA Receptor Subunits and BDNF after Intra-prefrontal Cortex Allopregnanolone Infusion in Rats
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.11.029
Abstract: Allopregnanolone is a neurosteroid implicated in mood disorders such as depression and anxiety. It acts as a GABAA receptor (GABAAR)-positive allosteric modulator and changes the expression of GABAAR subunits and of brain-derived neurotrophic factor (BDNF)… read more here.
Keywords: subunits bdnf; allopregnanolone infusion; infusion; mrna expression ... See more keywords
Allopregnanolone induces state-dependent fear via the bed nucleus of the stria terminalis
Sign Up to like & getrecommendations! Published in 2017 at "Hormones and Behavior"
DOI: 10.1016/j.yhbeh.2017.01.002
Abstract: &NA; Gonadal steroids and their metabolites have been shown to be important modulators of emotional behavior. Allopregnanolone (ALLO), for example, is a metabolite of progesterone that has been linked to anxiety‐related disorders such as posttraumatic… read more here.
Keywords: state; fear; state dependent; bed nucleus ... See more keywords
Effects of GABA active steroids in the female brain with a focus on the premenstrual dysphoric disorder
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.12553
Abstract: Premenstrual dysphoric disorder (PMDD) afflicts 3%‐5% of women of childbearing age, and is characterised by recurrent negative mood symptoms (eg, irritability, depression, anxiety and emotional lability) during the luteal phase of the menstrual cycle. The… read more here.
Keywords: phase; premenstrual dysphoric; dysphoric disorder; mood ... See more keywords
A theory of the anxiolytic action of flumazenil in anxiety disorders
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DOI: 10.1177/02698811221082466
Abstract: Background: Anxiety disorders are highly prevalent affecting up to 33.7% of people over a lifetime. Although many treatment options are available, they are often associated with unacceptable side-effect profiles and approximately one in three patients… read more here.
Keywords: anxiety disorders; allopregnanolone; action; gabaa receptor ... See more keywords
Inhibition of human macrophage activation via pregnane neurosteroid interactions with toll-like receptors: Sex differences and structural requirements
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.940095
Abstract: We recently discovered that (3α,5α)3-hydroxypregnan-20-one (allopregnanolone) inhibits pro-inflammatory toll-like receptor (TLR) activation and cytokine/chemokine production in mouse macrophage RAW264.7 cells. The present studies evaluate neurosteroid actions upon TLR activation in human macrophages from male and… read more here.
Keywords: toll like; inhibition; tlr4; allopregnanolone ... See more keywords
The Enantiomer of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.855779
Abstract: In an ex vivo rat ocular hypertension (OHT) model, the neurosteroid allopregnanolone (AlloP) exerts neuroprotective effects via enhancement of both GABAA receptors and autophagy. We now examine whether its enantiomer (ent-AlloP), which is largely inactive… read more here.
Keywords: vivo; pressure; allop; allopregnanolone ... See more keywords