GR3027 reversal of neurosteroid-induced, GABA-A receptor-mediated inhibition of human brain function: an allopregnanolone challenge study
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DOI: 10.1007/s00213-018-4864-1
Abstract: RationaleGR3027 is a novel small molecule GABA-A receptor-modulating steroid antagonist, which in non-clinical studies has shown promise for treatment of human disorders due to allosteric over-activation of GABA-A receptors by neurosteroids, such as allopregnanolone. We… read more here.
Keywords: brain function; gaba receptor; gr3027; allopregnanolone induced ... See more keywords