Thiopurines with low-dose allopurinol (ThiLDA)—a prospective clinical one-way crossover trial
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-019-02760-8
Abstract: Many patients with Crohn’s disease (CD) and ulcerative colitis (UC) who have a high 6-methylmercaptopurine/6-thioguanine (6-MMP/6-TGN) ratio receive allopurinol 100 mg in addition to thiopurines to optimize metabolite concentrations. However, some patients do not tolerate… read more here.
Keywords: way crossover; allopurinol; metabolite concentrations; one way ... See more keywords
Hyperuricaemia, gout and allopurinol in the CKD Queensland registry
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Nephrology"
DOI: 10.1007/s40620-020-00937-4
Abstract: There is scant data on the role of hyperuricaemia, gout and allopurinol treatment in chronic kidney disease (CKD). Therefore, our aim is to investigate the possible associations between hyperuricaemia, gout, prescription of allopurinol and renal… read more here.
Keywords: gout allopurinol; hyperuricaemia gout; ckd; gout ... See more keywords
The possible role of nitric oxide signaling and NMDA receptors in allopurinol effect on maximal electroshock- and pentylenetetrazol-induced seizures in mice
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2022.136620
Abstract: Allopurinol, a uric-acid-lowering medication, has shown its efficacy in several studies suggesting that allopurinol can be prescribed as adjunctive cure meant for intractable epilepsy. The exact mechanism of allopurinol is still unknown. This study evaluates… read more here.
Keywords: allopurinol; ptz induced; seizure; effect ... See more keywords
In vitro and in silico xanthine oxidase inhibitory potential of Benzofuran isolated from Viburnum grandiflorum Wall. Ex DC
Sign Up to like & getrecommendations! Published in 2021 at "South African Journal of Botany"
DOI: 10.1016/j.sajb.2021.01.010
Abstract: Abstract The study aimed to validate the folkloric medicinal uses of Viburnum grandiflorum. The column chromatography led to the isolation of a compound from the chloroform soluble fraction of V. grandiflorum which was characterized as… read more here.
Keywords: benzofuran; viburnum grandiflorum; xanthine oxidase; allopurinol ... See more keywords
Long-term cardiovascular safety of febuxostat compared with allopurinol in patients with gout (FAST): a multicentre, prospective, randomised, open-label, non-inferiority trial
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DOI: 10.1016/s0140-6736(20)32234-0
Abstract: BACKGROUND Febuxostat and allopurinol are urate-lowering therapies used to treat patients with gout. Following concerns about the cardiovascular safety of febuxostat, the European Medicines Agency recommended a post-licensing study assessing the cardiovascular safety of febuxostat… read more here.
Keywords: allopurinol; patients gout; non; febuxostat ... See more keywords
Surprising safety outcomes of urate-lowering therapy
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-018-0007-7
Abstract: © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature reviews | Rheumatology Febuxostat is noninferior to allopurinol with respect to rates of adverse cardiovascular events in patients with gout and cardiovascular… read more here.
Keywords: trial; group; study; rheumatology ... See more keywords
Effects of allopurinol on renal function in patients with diabetes: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2068443
Abstract: Abstract Background/Objective Diabetes mellitus is a common “non-gout” disease with high incidence. Several studies have shown that serum uric acid level in patients with diabetes is higher than that in healthy individuals, and is accompanied… read more here.
Keywords: meta analysis; allopurinol; analysis; renal function ... See more keywords
A case report on allopurinol induced crystalline maculopathy
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DOI: 10.1111/1756-185x.12827
Abstract: Dear Editor, Allopurinol hypersensitivity among susceptible individuals is widely reported. Nevertheless, ocular manifestations caused by allopurinol are rarely encountered. Here, we describe a case of a young Chinese woman diagnosed with gout and metabolic syndrome,… read more here.
Keywords: case; every night; crystalline maculopathy; crystalline ... See more keywords
Incidence of allopurinol-induced severe cutaneous adverse drug reaction in Malaysia.
Sign Up to like & getrecommendations! Published in 2022 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.15327
Abstract: INTRODUCTION Allopurinol is known to cause severe cutaneous adverse drug reactions (SCAR) in Malaysia. However, the incidence of allopurinol-induced SCAR is unknown. Therefore, we aimed to determine the incidence of allopurinol-induced SCAR in Malaysia over… read more here.
Keywords: induced scar; incidence allopurinol; allopurinol; allopurinol induced ... See more keywords
Optimising adherence to allopurinol for gout: patients' perspectives.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.15657
Abstract: AIMS Poor adherence to allopurinol among people with gout contributes to suboptimal gout management. This study sought to understand the facilitators and barriers to allopurinol adherence across the three stages of medication adherence, and patient… read more here.
Keywords: adherence; advice; gout; allopurinol ... See more keywords
An association study of ABCG2 rs2231142 on the concentrations of allopurinol and its metabolites
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13318
Abstract: ABCG2 is a gene that codes for the human breast cancer resistance protein (BCRP). It is established that rs2231142 G>T, a single nucleotide polymorphism of the ABCG2 gene, is associated with gout and poor response… read more here.
Keywords: allopurinol metabolites; allopurinol; association study; abcg2 rs2231142 ... See more keywords