HLA‐A*24:02 increase the risk of allopurinol‐induced drug reaction with eosinophilia and systemic symptoms in HLA‐B*58:01 carriers in a Korean population; a multicenter cross‐sectional case‐control study
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DOI: 10.1002/clt2.12193
Abstract: Abstract Background HLA‐B*58:01 is a well‐known risk factor for allopurinol‐induced severe cutaneous adverse reactions (SCARs). However, only a minority of HLA‐B*58:01 carriers suffer SCARs after taking allopurinol. The aim of this study was to investigate… read more here.
Keywords: dress; hla carriers; risk; allopurinol induced ... See more keywords
Incidence of allopurinol-induced severe cutaneous adverse drug reaction in Malaysia.
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DOI: 10.1111/bcp.15327
Abstract: INTRODUCTION Allopurinol is known to cause severe cutaneous adverse drug reactions (SCAR) in Malaysia. However, the incidence of allopurinol-induced SCAR is unknown. Therefore, we aimed to determine the incidence of allopurinol-induced SCAR in Malaysia over… read more here.
Keywords: induced scar; incidence allopurinol; allopurinol; allopurinol induced ... See more keywords
Clinical features, treatment outcomes and prognostic factors of allopurinol‐induced DRESS in 52 patients
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DOI: 10.1111/jcpt.13667
Abstract: Allopurinol‐induced drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but serious and potentially life‐threatening drug hypersensitivity syndrome. In this study, we aimed to investigate the clinical features, treatment outcomes, and prognostic factors… read more here.
Keywords: dress; outcomes prognostic; treatment outcomes; allopurinol induced ... See more keywords
Allopurinol‐induced Stevens‐Johnson syndrome and toxic epidermal necrolysis: Signal detection and preventability from Vietnam National pharmacovigilance database
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DOI: 10.1111/jcpt.13740
Abstract: Allopurinol, the first‐line medication for hyperuricemia is well‐known for its association with severe cutaneous adverse reactions, especially Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). In the current study, we analysed the Vietnamese spontaneous reporting… read more here.
Keywords: toxic epidermal; allopurinol induced; johnson syndrome; stevens johnson ... See more keywords
WGCNA-Based DNA Methylation Profiling Analysis on Allopurinol-Induced Severe Cutaneous Adverse Reactions: A DNA Methylation Signature for Predisposing Drug Hypersensitivity
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DOI: 10.3390/jpm12040525
Abstract: Background: The role of aberrant DNA methylation in allopurinol-induced severe cutaneous adverse reactions (SCARs) is incompletely understood. To fill the gap, we analyze the DNA methylation profiling in allopurinol-induced Stevens-Johnson syndrome (SJS) and toxic epidermal… read more here.
Keywords: allopurinol induced; methylation; dna methylation; methylation profiling ... See more keywords