Absence of recipient C3aR1 signaling limits expansion and differentiation of alloreactive CD8+ T cell immunity and prolongs murine cardiac allograft survival
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DOI: 10.1111/ajt.15222
Abstract: Activation, differentiation, and expansion of alloreactive CD8+ T cells, the dominant effectors that mediate murine heart allograft rejection, requires allorecognition, costimulation, and cytokine‐initiated signals. While previous work showed that alloreactive CD4+ T cell immunity entails… read more here.
Keywords: expansion; c3ar1; allograft; alloreactive cd8 ... See more keywords