Donor natural killer cells trigger production of beta-2-microglobulin to enhance post bone marrow transplant immunity.
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DOI: 10.1182/blood.2021015297
Abstract: Allogeneic hematopoietic transplantation is a powerful treatment for hematologic malignancies. Post-transplant immune incompetence exposes patients to disease relapse and infections. We previously demostrated that donor alloreactive natural killer (NK) cells ablate recipient hematopoietic targets, including… read more here.
Keywords: b2m; alloreactive cells; natural killer; killer cells ... See more keywords
Metabolic Pathways in Alloreactive T Cells
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DOI: 10.3389/fimmu.2020.01517
Abstract: Allogeneic hematopoietic stem cell transplantation (aHSCT) is a curative therapy for a range of hematologic illnesses including aplastic anemia, sickle cell disease, immunodeficiency, and high-risk leukemia, but the efficacy of aHSCT is often undermined by… read more here.
Keywords: metabolism; metabolic pathways; cell metabolism; pathways alloreactive ... See more keywords
Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect
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DOI: 10.3389/fimmu.2022.751296
Abstract: Alloreactive donor T cells undergo extensive metabolic reprogramming to become activated and induce graft-versus-host disease (GVHD) upon alloantigen encounter. It is generally thought that glycolysis, which promotes T cell growth and clonal expansion, is employed… read more here.
Keywords: gvhd; alloreactive cells; graft versus; glycolysis ... See more keywords
Pre-existing Alloreactive T and B Cells and Their Possible Relevance for Pre-transplant Risk Estimation in Kidney Transplant Recipients
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DOI: 10.3389/fmed.2020.00340
Abstract: In allogeneic transplantation, genetic disparities between patient and donor may lead to cellular and humoral immune responses mediated by both naïve and memory alloreactive cells of the adaptive immune system. This review will focus on… read more here.
Keywords: kidney transplant; transplant risk; transplant; alloreactive cells ... See more keywords