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   Articles with "alloreactive cells" as a keyword



Overcoming NK Cell-Mediated Allograft Rejection By Anti-3rd Party Central Memory Veto CD8 T Cells through Down-Regulation of the Activating Receptor DNAM-1 on Alloreactive NK Cells

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-203601

Abstract: Allograft rejection is a major challenge for allogeneic chimeric antigen receptor (CAR) cell therapy, particularly due to host T and NK cell responses. Previous studies demonstrated that anti-third-party central memory CD8 veto T cells (Tcm)… read more here.

Keywords: veto; veto cells; rejection; culture ... See more keywords

Donor natural killer cells trigger production of beta-2-microglobulin to enhance post bone marrow transplant immunity.

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recommendations! Published in 2022 at "Blood"

DOI: 10.1182/blood.2021015297

Abstract: Allogeneic hematopoietic transplantation is a powerful treatment for hematologic malignancies. Post-transplant immune incompetence exposes patients to disease relapse and infections. We previously demostrated that donor alloreactive natural killer (NK) cells ablate recipient hematopoietic targets, including… read more here.

Keywords: b2m; alloreactive cells; natural killer; killer cells ... See more keywords

Metabolic Pathways in Alloreactive T Cells

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recommendations! Published in 2020 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2020.01517

Abstract: Allogeneic hematopoietic stem cell transplantation (aHSCT) is a curative therapy for a range of hematologic illnesses including aplastic anemia, sickle cell disease, immunodeficiency, and high-risk leukemia, but the efficacy of aHSCT is often undermined by… read more here.

Keywords: metabolism; metabolic pathways; cell metabolism; pathways alloreactive ... See more keywords

Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.751296

Abstract: Alloreactive donor T cells undergo extensive metabolic reprogramming to become activated and induce graft-versus-host disease (GVHD) upon alloantigen encounter. It is generally thought that glycolysis, which promotes T cell growth and clonal expansion, is employed… read more here.

Keywords: gvhd; alloreactive cells; graft versus; glycolysis ... See more keywords
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Pre-existing Alloreactive T and B Cells and Their Possible Relevance for Pre-transplant Risk Estimation in Kidney Transplant Recipients

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recommendations! Published in 2020 at "Frontiers in Medicine"

DOI: 10.3389/fmed.2020.00340

Abstract: In allogeneic transplantation, genetic disparities between patient and donor may lead to cellular and humoral immune responses mediated by both naïve and memory alloreactive cells of the adaptive immune system. This review will focus on… read more here.

Keywords: kidney transplant; transplant risk; transplant; alloreactive cells ... See more keywords