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   Articles with "allosteric activation" as a keyword



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Orthosteric and Allosteric Activation of Human 5-HT3A Receptors.

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recommendations! Published in 2020 at "Biophysical journal"

DOI: 10.1016/j.bpj.2020.08.029

Abstract: The serotonin type 3 receptor (5-HT3) is a ligand-gated ion channel that converts the binding of the neurotransmitter serotonin (5-HT) into a transient cation current that mediates fast excitatory responses in peripheral and central nervous… read more here.

Keywords: orthosteric allosteric; human ht3a; activation; allosteric activation ... See more keywords
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Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss.

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recommendations! Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.109872

Abstract: SARM1 is an inducible TIR-domain NAD+ hydrolase that mediates pathological axon degeneration. SARM1 is activated by an increased ratio of NMN to NAD+, which competes for binding to an allosteric activating site. When NMN binds,… read more here.

Keywords: sarm1; subvert allosteric; allosteric activation; neurotoxins subvert ... See more keywords
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Insight into the mechanism of allosteric activation of PI3Kα by oncoprotein K-Ras4B.

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recommendations! Published in 2019 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2019.12.020

Abstract: Ras is a key member in the superfamily of small GTPase. Transforming between GTP-bound active state and GDP-bound inactive state in response to exogenous signals, Ras serves as a binary switch in various signaling pathways.… read more here.

Keywords: state; pi3k; ras4b; activation pi3k ... See more keywords
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Allosteric Activation of PI3Kα Results in Dynamic Access to Catalytically Competent Conformations.

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recommendations! Published in 2020 at "Structure"

DOI: 10.1016/j.str.2020.01.010

Abstract: Class I phosphoinositide-3-kinases (PI3Ks) phosphorylate PIP2 at its 3' inositol position to generate PIP3, a second messenger that influences signaling cascades regulating cellular growth, survival, and proliferation. Previous studies have suggested that PI3Kα activation involves… read more here.

Keywords: pi3k; activation pi3k; allosteric activation; nsh2 domain ... See more keywords
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Time Evolution of the Millisecond Allosteric Activation of Imidazole Glycerol Phosphate Synthase

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recommendations! Published in 2022 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.1c12629

Abstract: Deciphering the molecular mechanisms of enzymatic allosteric regulation requires the structural characterization of functional states and also their time evolution toward the formation of the allosterically activated ternary complex. The transient nature and usually slow… read more here.

Keywords: time; allosteric activation; time evolution; activation imidazole ... See more keywords
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Evolutionary conservation of the allosteric activation of factor VIIa by tissue factor in lamprey: comment

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recommendations! Published in 2018 at "Journal of Thrombosis and Haemostasis"

DOI: 10.1111/jth.14142

Abstract: We read with great interest the article on allostery in a protease from the blood coagulation cascade by Beeler et al.(1) in a recent issue of Journal of Thrombosis and Haemostasis. Herein, the authors conclude that… read more here.

Keywords: factor viia; coagulation; factor lamprey; tissue factor ... See more keywords
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Ca2+ binding induced sequential allosteric activation of sortase A: An example for ion-triggered conformational selection

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recommendations! Published in 2018 at "PLoS ONE"

DOI: 10.1371/journal.pone.0205057

Abstract: The allosteric activation of the intrinsically disordered enzyme Staphylococcus aureus sortase A is initiated via binding of a Ca2+ ion. Although Ca2+ binding was shown to initiate structural changes inducing disorder-to-order transitions, the details of… read more here.

Keywords: ca2 binding; allosteric activation; sortase; activation ... See more keywords
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Allosteric activation of yeast enzyme neutral trehalase by calcium and 14-3-3 protein.

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recommendations! Published in 2019 at "Physiological research"

DOI: 10.33549/physiolres.933950

Abstract: Neutral trehalase 1 (Nth1) from Saccharomyces cerevisiae catalyzes disaccharide trehalose hydrolysis and helps yeast to survive adverse conditions, such as heat shock, starvation or oxidative stress. 14-3-3 proteins, master regulators of hundreds of partner proteins,… read more here.

Keywords: protein; neutral trehalase; activation yeast; activation ... See more keywords
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Tuning site-specific dynamics to drive allosteric activation in a pneumococcal zinc uptake regulator

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recommendations! Published in 2018 at "eLife"

DOI: 10.7554/elife.37268

Abstract: MarR (multiple antibiotic resistance repressor) family proteins are bacterial repressors that regulate transcription in response to a wide range of chemical signals. Although specific features of MarR family function have been described, the role of… read more here.

Keywords: site specific; tuning site; specific dynamics; activation ... See more keywords