Mapping the Allosteric Communication Network of Aminodeoxychorismate Synthase.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.05.021
Abstract: Allosteric communication between different subunits in metabolic enzyme complexes is of utmost physiological importance but only understood for few systems. We analyzed the structural basis of allostery in aminodeoxychorismate synthase (ADCS), which is a member… read more here.
Keywords: network; aminodeoxychorismate synthase; allosteric communication; active site ... See more keywords
Structural Analysis of the Regulatory GAF Domains of cGMP Phosphodiesterase Elucidates the Allosteric Communication Pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.08.026
Abstract: Regulation of photoreceptor phosphodiesterase (PDE6) activity is responsible for the speed, sensitivity, and recovery of the photoresponse during visual signaling in vertebrate photoreceptor cells. It is hypothesized that physiological differences in the light responsiveness of… read more here.
Keywords: phosphodiesterase; allosteric communication; gaf domains; cone ... See more keywords
Toward Comprehensive Allosteric Control over Protein Activity.
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DOI: 10.1016/j.str.2019.01.014
Abstract: Universality of allosteric signaling in proteins, molecular machines, and receptors complemented by the great advantages of prospected allosteric drugs in the highly specific, non-competitive, and modulatory nature of their actions calls for deeper theoretical understanding… read more here.
Keywords: protein activity; allosteric control; allosteric communication;
A non-equilibrium approach to allosteric communication
Sign Up to like & getrecommendations! Published in 2018 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2017.0187
Abstract: While the theory of protein folding is well developed, including concepts such as rugged energy landscape, folding funnel, etc., the same degree of understanding has not been reached for the description of the dynamics of… read more here.
Keywords: approach allosteric; non equilibrium; equilibrium approach; allosteric communication ... See more keywords