Insights into allosteric control of microtubule dynamics from a buried β‐tubulin mutation that causes faster growth and slower shrinkage
Sign Up to like & getrecommendations! Published in 2020 at "Protein Science"
DOI: 10.1002/pro.3842
Abstract: αβ‐tubulin subunits cycle through a series of different conformations in the polymer lattice during microtubule growing and shrinking. How these allosteric responses to different tubulin:tubulin contacts contribute to microtubule dynamics, and whether the contributions are… read more here.
Keywords: microtubule; allosteric control; microtubule dynamics; tubulin ... See more keywords
Toward Comprehensive Allosteric Control over Protein Activity.
Sign Up to like & getrecommendations! Published in 2019 at "Structure"
DOI: 10.1016/j.str.2019.01.014
Abstract: Universality of allosteric signaling in proteins, molecular machines, and receptors complemented by the great advantages of prospected allosteric drugs in the highly specific, non-competitive, and modulatory nature of their actions calls for deeper theoretical understanding… read more here.
Keywords: protein activity; allosteric control; allosteric communication;
Allosteric Control of Peroxidase-Mimicking DNAzyme Activity with Cationic Copolymers.
Sign Up to like & getrecommendations! Published in 2018 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.8b00201
Abstract: Control of protein conformation and function, induced by the binding of an effector, plays significant roles in modulating biochemical reaction. Although the DNAzymes catalytic activity is similar to protein-based enzymes, reports of allosterically controlled DNAzymes… read more here.
Keywords: dnazyme activity; mimicking dnazyme; allosteric control; activity ... See more keywords
Allosteric Control of Photofoldamers for Selecting between Anion Regulation and Double-to-Single Helix Switching.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b10538
Abstract: Allosteric regulation of protein structure and function is a hallmark of biology. The structures of protein-like abiological foldamers have been subject to allosteric control, however, regulation of their function is rare. We report this behavior… read more here.
Keywords: anion; single helix; structure; allosteric control ... See more keywords
Host–Guest Allosteric Control of an Artificial Phosphatase
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b12699
Abstract: The activity of many enzymes is regulated by associative processes. To model this mechanism, we report here that the conformation of an unstructured bimetallic Zn(II) complex can be controlled by its inclusion in the cavity… read more here.
Keywords: guest allosteric; control artificial; host guest; allosteric control ... See more keywords
Zinc-mediated conformational preselection mechanism in the allosteric control of DNA binding to the zinc transcriptional regulator (ZitR)
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-70381-8
Abstract: The zinc transcriptional regulator (ZitR) functions as a metalloregulator that fine tunes transcriptional regulation through zinc-dependent DNA binding. However, the molecular mechanism of zinc-driven allosteric control of the DNA binding to ZitR remains elusive. Here,… read more here.
Keywords: zitr; dna; zinc; control dna ... See more keywords
Protein kinase C showcases allosteric control: activation of LRRK1
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Journal"
DOI: 10.1042/bcj20220507
Abstract: Allosteric regulation of multi-domain protein kinases provides a common mechanism to acutely control kinase activity. Protein kinase C serves as a paradigm for multi-domain proteins whose activity is exquisitely tuned by interdomain conformational changes that… read more here.
Keywords: protein kinase; showcases allosteric; kinase showcases; allosteric control ... See more keywords
Engineering protein assemblies with allosteric control via monomer fold-switching.
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.2210/pdb6qiz/pdb
Abstract: The macromolecular machines of life use allosteric control to self-assemble, dissociate and change shape in response to signals. Despite enormous interest, the design of nanoscale allosteric assemblies has proven tremendously challenging. Here we present a… read more here.
Keywords: engineering protein; monomer; protein assemblies; allosteric control ... See more keywords
Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.26985
Abstract: GPCRs play critical roles in cell communication. Although GPCRs can form heteromers, their role in signaling remains elusive. Here we used rat metabotropic glutamate (mGlu) receptors as prototypical dimers to study the functional interaction between… read more here.
Keywords: transduction protein; control asymmetric; protein coupled; transduction ... See more keywords