Unraveling the Allosteric Cross-Talk between the Coactivator Peptide and the Ligand-Binding Site in the Glucocorticoid Receptor
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c00323
Abstract: The glucocorticoid receptor (GR) is a nuclear receptor that controls critical biological processes by regulating the transcription of specific genes. There is a known allosteric cross-talk between the ligand and coregulator binding sites within the… read more here.
Keywords: cross talk; ligand; receptor; allosteric cross ... See more keywords
Allosteric cross-talk in chromatin can mediate drug-drug synergy
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DOI: 10.1038/ncomms14860
Abstract: Exploitation of drug–drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug–drug synergy mediated by allosteric… read more here.
Keywords: cross talk; allosteric cross; chromatin; drug ... See more keywords