Allostery: Allosteric Cancer Drivers and Innovative Allosteric Drugs.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2022.167569
Abstract: Here, we discuss the principles of allosteric activating mutations, propagation downstream of the signals that they prompt, and allosteric drugs, with examples from the Ras signaling network. We focus on Abl kinase where mutations shift… read more here.
Keywords: allosteric cancer; innovative allosteric; allosteric drugs; drivers innovative ... See more keywords
Allosteric Methods and Their Applications: Facilitating the Discovery of Allosteric Drugs and the Investigation of Allosteric Mechanisms.
Sign Up to like & getrecommendations! Published in 2019 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.8b00570
Abstract: Allostery, or allosteric regulation, is the phenomenon in which protein functional activity is altered by the binding of an effector at an allosteric site that is topographically distinct from the orthosteric, active site. As one… read more here.
Keywords: allosteric drugs; allosteric sites; discovery; investigation allosteric ... See more keywords