2-Substituted thienotetrahydropyridine derivatives: Allosteric ectonucleotidase inhibitors.
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DOI: 10.1002/ardp.202100300
Abstract: The antithrombotic prodrugs ticlopidine and clopidogrel are thienotetrahydro-pyridine derivatives that are metabolized in the liver to produce thiols that irreversibly block adenosine diphosphate (ADP)-activated P2Y12 receptors on thrombocytes. In their native, nonmetabolized form, both drugs… read more here.
Keywords: allosteric ectonucleotidase; derivatives allosteric; substituted thienotetrahydropyridine; ectonucleotidase inhibitors ... See more keywords