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   Articles with "allosteric effectors" as a keyword



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Design, Synthesis, and Evaluation of Allosteric Effectors for Hemoglobin.

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recommendations! Published in 2023 at "Accounts of chemical research"

DOI: 10.1021/acs.accounts.2c00590

Abstract: ConspectusSickle cell disease (SCD) is an inherited blood disorder caused by a point mutation in hemoglobin (Hb), the protein in the red blood cell (RBC) responsible for the transport of oxygen (O2) throughout the body.… read more here.

Keywords: design synthesis; evaluation allosteric; scd; hbs ... See more keywords
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Design, Synthesis, and Biological Evaluation of Allosteric Effectors That Enhance CO Release from Carboxyhemoglobin.

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recommendations! Published in 2018 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.8b00166

Abstract: Carbon monoxide (CO) poisoning causes between 5,000-6,000 deaths per year in the US alone. The development of small molecule allosteric effectors of CO binding to hemoglobin (Hb) represents an important step toward making effective therapies… read more here.

Keywords: design synthesis; biological evaluation; allosteric effectors; enhance release ... See more keywords

Mutational mimics of allosteric effectors: a genome editing design to validate allosteric drug targets

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-45202-2

Abstract: Development of drugs that allosterically regulate enzyme functions to treat disease is a costly venture. Amino acid susbstitutions that mimic allosteric effectors in vitro will identify therapeutic regulatory targets enhancing the likelihood of developing a… read more here.

Keywords: hlpyk; effectors genome; point mutations; allosteric effectors ... See more keywords
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Slow dynamics measured by phosphorescence lifetime reveals global conformational changes in human adult hemoglobin induced by allosteric effectors

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recommendations! Published in 2022 at "PLOS ONE"

DOI: 10.1371/journal.pone.0278417

Abstract: The mechanism underlying allostery in hemoglobin (Hb) is still not completely understood. Various models describing the action of allosteric effectors on Hb function have been published in the literature. It has also been reported that… read more here.

Keywords: phosphorescence; hemoglobin; allosteric effectors; activation ... See more keywords
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The PII-NAGK-PipX-NtcA Regulatory Axis of Cyanobacteria: A Tale of Changing Partners, Allosteric Effectors and Non-covalent Interactions

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recommendations! Published in 2018 at "Frontiers in Molecular Biosciences"

DOI: 10.3389/fmolb.2018.00091

Abstract: PII, a homotrimeric very ancient and highly widespread (bacteria, archaea, plants) key sensor-transducer protein, conveys signals of abundance or poorness of carbon, energy and usable nitrogen, converting these signals into changes in the activities of… read more here.

Keywords: nitrogen; pii pipx; allosteric effectors; pipx ... See more keywords