LAUSR

Allosteric HIV integrase inhibitors promote formation of inactive branched polymers via homomeric carboxy-terminal domain interactions.

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0 Published in 2020 at "Structure"

DOI: 10.1016/j.str.2020.12.001

Abstract: The major effect of allosteric HIV integrase (IN) inhibitors (ALLINIs) is observed during virion maturation, where ALLINI treatment interrupts IN-RNA interactions via drug-induced IN aggregation, leading to the formation of aberrant virions. To understand the… read more here.

Keywords: integrase inhibitors; carboxy terminal; formation; homomeric carboxy ... See more keywords