Deep mutational scanning and machine learning reveal structural and molecular rules governing allosteric hotspots in homologous proteins
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DOI: 10.1101/2022.05.01.490188
Abstract: A fundamental question in protein science is where allosteric hotspots – residues critical for allosteric signaling – are located, and what properties differentiate them. We carried out deep mutational scanning (DMS) of four homologous bacterial… read more here.
Keywords: structural molecular; allosteric hotspots; machine learning; deep mutational ... See more keywords