Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies
Sign Up to like & getrecommendations! Published in 2020 at "Cell Chemical Biology"
DOI: 10.1016/j.chembiol.2020.06.006
Abstract: Summary Camelid single-domain antibody fragments (nanobodies) offer the specificity of an antibody in a single 15-kDa immunoglobulin domain. Their small size allows for easy genetic manipulation of the nanobody sequence to incorporate protein tags, facilitating… read more here.
Keywords: monitoring allosteric; hibit; allosteric interactions; interactions cxcr4 ... See more keywords
Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.03.018
Abstract: During development of the central nervous system, there is a shift in the subunit composition of NMDA receptors (NMDARs) resulting in a dramatic acceleration of NMDAR-mediated synaptic currents. This shift coincides with upregulation of the… read more here.
Keywords: shift; glun1 nmdars; interactions nmda; nmda receptor ... See more keywords
A structural comparison of ‘real’ and ‘model’ calmodulin clarified allosteric interactions regulating domain motion
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1462730
Abstract: Calmodulin (CaM) is a multifunctional calcium-binding protein, which regulates various biochemical processes. CaM acts via structural changes and complex forming with its target enzymes. CaM has two globular domains (N-lobe and C-lobe) connected by a… read more here.
Keywords: motion; cam; allosteric interactions; model ... See more keywords
Stacking-induced fluorescence increase reveals allosteric interactions through DNA
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky887
Abstract: Abstract From gene expression to nanotechnology, understanding and controlling DNA requires a detailed knowledge of its higher order structure and dynamics. Here we take advantage of the environment-sensitive photoisomerization of cyanine dyes to probe local… read more here.
Keywords: stacking induced; induced fluorescence; allosteric interactions; increase reveals ... See more keywords
Computer Simulations and Network-Based Profiling of Binding and Allosteric Interactions of SARS-CoV-2 Spike Variant Complexes and the Host Receptor: Dissecting the Mechanistic Effects of the Delta and Omicron Mutations
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23084376
Abstract: In this study, we combine all-atom MD simulations and comprehensive mutational scanning of S-RBD complexes with the angiotensin-converting enzyme 2 (ACE2) host receptor in the native form as well as the S-RBD Delta and Omicron… read more here.
Keywords: network; allosteric interactions; omicron mutations; host receptor ... See more keywords