A synthetic human antibody antagonizes IL-18Rβ signaling through an allosteric mechanism.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.01.012
Abstract: The interleukin-18 subfamily belongs to the interleukin-1 family and plays important roles in modulating innate and adaptive immune responses. Dysregulation of IL-18 has been implicated in or correlated with numerous diseases including inflammatory diseases, autoimmune… read more here.
Keywords: antibody antagonizes; allosteric mechanism; synthetic human; human antibody ... See more keywords
Dissecting a novel allosteric mechanism of cruzain: A computer-aided approach
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0211227
Abstract: Trypanosoma cruzi is the causative agent of Chagas disease, a neglected infection affecting millions of people in tropical regions. There are several chemotherapeutic agents for the treatment of this disease, but most of them are… read more here.
Keywords: novel allosteric; allosteric inhibitors; site; allosteric mechanism ... See more keywords