Proteome-Scale Investigation of Protein Allosteric Regulation Perturbed by Somatic Mutations in 7,000 Cancer Genomes.
Sign Up to like & getrecommendations! Published in 2017 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2016.09.020
Abstract: The allosteric regulation triggering the protein's functional activity via conformational changes is an intrinsic function of protein under many physiological and pathological conditions, including cancer. Identification of the biological effects of specific somatic variants on allosteric… read more here.
Keywords: cancer; cancer genomes; allosteric regulation; protein allosteric ... See more keywords
Conformational Dynamics and Allosteric Regulation Landscapes of Germline PTEN Mutations Associated with Autism Compared to Those Associated with Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2019.03.009
Abstract: Individuals with germline PTEN tumor-suppressor variants have PTEN hamartoma tumor syndrome (PHTS). Clinically, PHTS has variable presentations; there are distinct subsets of PHTS-affected individuals, such as those diagnosed with autism spectrum disorder (ASD) or cancer.… read more here.
Keywords: allosteric regulation; structural communication; cancer; asd cancer ... See more keywords
Allosteric regulation of arylamine N‐acetyltransferase 1 by adenosine triphosphate
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.10.013
Abstract: &NA; In the present study, a screen of adenosine analogs as potential modulators of arylamine‐N‐acetyltransferase 1 activity identified ATP as an inhibitor within its range of physiological concentrations. Kinetically, ATP was a non‐competitive inhibitor with… read more here.
Keywords: allosteric regulation; acetyltransferase; lysine 100; triphosphate ... See more keywords
Allosteric Regulation of Glycogen Phosphorylase by Order/Disorder Transition of the 250′ and 280s Loops
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00671
Abstract: Allostery is a fundamental mechanism of protein activation, yet the precise dynamic changes that underlie functional regulation of allosteric enzymes, such as glycogen phosphorylase (GlyP), remain poorly understood. Despite being the first allosteric enzyme described,… read more here.
Keywords: allosteric regulation; glyp; 250 280s; glycogen phosphorylase ... See more keywords
Allosteric Regulation in Carbon Monoxide (CO) Release: Anion Responsive CO-Releasing Molecule (CORM) Derived from (Terpyridine)phenol Manganese Tricarbonyl Complex with Colorimetric and Fluorescence Monitoring.
Sign Up to like & getrecommendations! Published in 2019 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.9b00984
Abstract: A new CO-releasing terpyridine based manganese(I) tricarbonyl complex, [MnBr(CO)3(terpy-C6H4OH)] (1·Mn-OH) functioning via light has been reported. For the first time, we have demonstrated the allosteric regulation concept to control the CO-releasing properties of a CO-releasing… read more here.
Keywords: allosteric regulation; manganese tricarbonyl; releasing molecule; tricarbonyl complex ... See more keywords
Molecular Mechanism of Ca2+ in the Allosteric Regulation of Human Parathyroid Hormone Receptor-1.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c00471
Abstract: Parathyroid hormone (PTH) is an endogenous ligand that activates the PTH type 1 receptor (PTH1R) signaling. Ca2+, a common second messenger, acts as an allosteric regulator for prolonging the activation of PTH1R. However, a clear… read more here.
Keywords: pth; allosteric regulation; mechanism; pth1r ... See more keywords
Uncovering the Dominant Motion Modes of Allosteric Regulation Improves Allosteric Site Prediction
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c01267
Abstract: Allostery is an important mechanism that biological systems use to regulate function at a distant site. Allosteric drugs have attracted much attention in recent years due to their high specificity and the possibility of overcoming… read more here.
Keywords: site prediction; motion; prediction; allosteric site ... See more keywords
Allosteric Regulation of IGF2BP1 as a Novel Strategy for the Activation of Tumor Immune Microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "ACS Central Science"
DOI: 10.1021/acscentsci.2c00107
Abstract: Tumor immune microenvironment (TIME) regulators are promising cancer immunotherapeutic targets. IGF2BP1, as a crucial N6-methyladenosine (m6A) reader protein, recognizes m6A target transcripts, ultimately leading to cancer development. However, currently, the biological function of IGF2BP1 in… read more here.
Keywords: allosteric regulation; immune microenvironment; tumor immune; tumor ... See more keywords
Allosteric Regulation of DNAzyme Activities through Intrastrand Transformation Induced by Cu(II)-Mediated Artificial Base Pairing.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c03129
Abstract: Allosteric regulation is gaining increasing attention as a basis for production of stimuli-responsive materials in many research areas including DNA nanotechnology. We expected that metal-mediated artificial base pairs, consisting of ligand-type nucleotides and a bridging… read more here.
Keywords: allosteric regulation; dnazyme; mediated artificial; base ... See more keywords
Structural basis for allosteric regulation of Human Topoisomerase IIα
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23136-6
Abstract: The human type IIA topoisomerases (Top2) are essential enzymes that regulate DNA topology and chromosome organization. The Topo IIα isoform is a prime target for antineoplastic compounds used in cancer therapy that form ternary cleavage… read more here.
Keywords: human topoisomerase; structural basis; allosteric regulation; basis allosteric ... See more keywords
Allosteric regulation of rotational, optical and catalytic properties within multicomponent machinery.
Sign Up to like & getrecommendations! Published in 2020 at "Dalton transactions"
DOI: 10.1039/d0dt01961e
Abstract: The reversible transformation of multicomponent nanorotors (ROT-1, k298 = 44 kHz or ROT-2, k298 = 61 kHz) to the "dimeric" supramolecular structures (DS-1 or DS-2, k298 = 0.60 kHz) was triggered by a stoichiometric chemical… read more here.
Keywords: allosteric regulation; rotational optical; machinery; regulation rotational ... See more keywords