Network Analysis of Molecular Dynamics Sectors in the p53 Protein
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DOI: 10.1021/acsomega.2c05635
Abstract: Design of allosteric regulators is an emergent field in the area of drug discovery holding promise for currently untreated diseases. Allosteric regulators bind to a protein in one location and affect a distant site. The… read more here.
Keywords: network; sector; molecular dynamics; sector residues ... See more keywords
Allosteric regulators selectively prevent Ca2+-feedback of CaV and NaV channels
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DOI: 10.7554/elife.35222
Abstract: Calmodulin (CaM) serves as a pervasive regulatory subunit of CaV1, CaV2, and NaV1 channels, exploiting a functionally conserved carboxy-tail element to afford dynamic Ca2+-feedback of cellular excitability in neurons and cardiomyocytes. Yet this modularity counters… read more here.
Keywords: cam; regulators selectively; allosteric regulators; ca2 feedback ... See more keywords