Abstract 1176: Preclinical characterization of the pharmacokinetic-pharmacodynamics-efficacy relationship of novel allosteric SHP2 inhibitors
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DOI: 10.1158/1538-7445.am2017-1176
Abstract: SHP2 is a non-receptor protein tyrosine phosphatase downstream of receptor tyrosine kinases (RTK). Mutations yielding constitutive activation of SHP2 primarily lead to activation of the MAPK pathway and have been found in multiple tumor types.… read more here.
Keywords: novel allosteric; shp2; allosteric shp2; shp2 inhibitors ... See more keywords