Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8719-7_11
Abstract: Deregulation of protein kinase activity has been linked to many diseases ranging from cancer to AIDS and neurodegenerative diseases. Not surprisingly, drugging the human kinome - the complete set of kinases encoded by the human… read more here.
Keywords: kinase inhibitors; serine threonine; kinase; atp binding ... See more keywords
Allosteric small molecule modulators of nuclear receptors
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2019.01.022
Abstract: Nuclear Receptors (NRs) are multi-domain proteins, whose natural regulation occurs via ligands for a classical, orthosteric, binding pocket and via intra- and inter-domain allosteric mechanisms. Allosteric modulation of NRs via synthetic small molecules has recently… read more here.
Keywords: nuclear receptors; small molecule; small molecules; molecule modulators ... See more keywords