Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1.
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DOI: 10.1016/j.molcel.2019.12.003
Abstract: Lipid droplets (LDs) provide a reservoir for triacylglycerol storage and are a central hub for fatty acid trafficking and signaling in cells. Lipolysis promotes mitochondrial biogenesis and oxidative metabolism via a SIRT1/PGC-1α/PPARα-dependent pathway through an… read more here.
Keywords: allosterically activate; activate sirt1; fatty acids; derived monounsaturated ... See more keywords