Conformational Dynamics and Allostery in E2:E3 Interactions Drive Ubiquitination: gp78 and Ube2g2.
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DOI: 10.1016/j.str.2017.03.016
Abstract: Conformational dynamics plays a fundamental role in molecular recognition and activity in enzymes. The ubiquitin-conjugating enzyme (E2) Ube2g2 functions with the ubiquitin ligase (E3) gp78 to assemble poly-ubiquitin chains on target substrates. Two domains in… read more here.
Keywords: conformational dynamics; interactions drive; allostery interactions; dynamics allostery ... See more keywords