Radical-mediated sulfonyl alkynylation, allylation, and cyanation of propellane.
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DOI: 10.1039/d1cc02249k
Abstract: Bicyclo[1.1.1]pentane (BCP) is widely applied as the bioisostere for aryl, internal alkynes, and tert-butyl groups in medicinal chemistry. We herein disclose an efficient and practical preparation of sulfonyl alkynyl/allyl/cyano-substituted BCP derivatives through a novel radical-mediated… read more here.
Keywords: alkynylation allylation; allylation cyanation; propellane; radical mediated ... See more keywords