Controllable Pd-Catalyzed Allylation of Indoles with Skipped Enynes: Divergent Synthesis of Indolenines and N-Allylindoles.
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DOI: 10.1021/acs.orglett.8b02481
Abstract: An unprecedented acid- and ligand-controlled divergent allylation of indoles with unactivated skipped enynes via Pd hydride catalysis has been disclosed. This redox-neutral transformation went through multiple hydropalladation insertion, β-hydrogen elimination, π-σ-π isomerization, and allylic substitution… read more here.
Keywords: catalyzed allylation; skipped enynes; controllable catalyzed; indolenines allylindoles ... See more keywords
Weak Coordination-Guided Regioselective Direct Redox-Neutral C4 Allylation of Indoles with Morita-Baylis-Hillman Adducts.
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DOI: 10.1021/acs.orglett.9b03823
Abstract: A weak carbonyl coordination-guided regioselective C4 allylation of indoles is demonstrated using the versatile Morita-Baylis-Hillman adduct in the presence of Rh catalysts in a redox-neutral fashion. The substrate scope, functional group diversity, oxidant free character,… read more here.
Keywords: morita baylis; baylis hillman; guided regioselective; coordination guided ... See more keywords
B(3,4,5-F3H2C6)3 Lewis acid-catalysed C3-allylation of indoles.
Sign Up to like & getrecommendations! Published in 2023 at "Dalton transactions"
DOI: 10.1039/d3dt00745f
Abstract: Herein we report the B(3,4,5-F3H2C6)3-catalysed C3-allylation of indoles using allylic esters. 25 examples of C3-allylated products are presented in up to 97% yield. The mechanism for the reaction was explored using detailed Density Functional Theory… read more here.
Keywords: catalysed allylation; acid catalysed; lewis acid; f3h2c6 lewis ... See more keywords