Asymmetric Synthesis of Chiral Aza-macrodiolides via Iridium-Catalyzed Cascade Allylation/Macrolactonization.
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DOI: 10.1021/acs.orglett.2c00942
Abstract: Iridium-catalyzed cascade allylation/macrolactonization between vinylethylene carbonate (VEC) and isatoic anhydride derivatives was successfully developed, readily generating a wide range of C2-symmetric chiral macrodiolides bearing 14-membered rings in moderate to good yields with excellent diastereoselectivities and… read more here.
Keywords: allylation macrolactonization; iridium; catalyzed cascade; iridium catalyzed ... See more keywords