Regio- and stereoselective syntheses of chiral α-quaternary (Z)-trisubstituted allylic amino acids via synergistic Pd/Cu catalysis.
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DOI: 10.1039/d2cc06820f
Abstract: Synergistic palladium/copper catalysis for asymmetric allylic alkylation of vinylethylene carbonates with aldimine esters has been developed for the synthesis of α-quaternary (Z)-trisubstituted allylic amino acids under mild conditions. This methodology features broad substrate compatibilities in… read more here.
Keywords: quaternary trisubstituted; amino acids; catalysis; allylic amino ... See more keywords