Site-Selective Functionalization of Unactivated Allylic C–H Bonds via Direct Deprotonation with KTMP: Application to the Formal Total Synthesis of (+)-Artemisinin from Amorphadiene
Sign Up to like & getrecommendations! Published in 2023 at "Organic Letters"
DOI: 10.1021/acs.orglett.2c04145
Abstract: The site-selective functionalization of unactivated allylic C–H bonds via direct deprotonation using KTMP is described. The conversion of amorphadiene to artemisinic alcohol via a simple, highly regioselective deprotonation over 4 other possible allylic sites is… read more here.
Keywords: functionalization unactivated; site selective; allylic bonds; selective functionalization ... See more keywords
Photochemical Organocatalytic Benzylation of Allylic C-H Bonds.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c11712
Abstract: We report a radical-based organocatalytic method for the direct benzylation of allylic C-H bonds. The process uses nonfunctionalized allylic substrates and readily available benzyl radical precursors and is driven by visible light. Crucial was the… read more here.
Keywords: organocatalytic benzylation; allylic bonds; benzylation allylic; chemistry ... See more keywords