Photoredox-Catalyzed Allylic Defluorinative Alkoxycarbonylation of Trifluoromethyl Alkenes through Intermolecular Alkoxycarbonyl Radical Addition.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04359
Abstract: The gem-difluoroalkene moiety is an ideal carbonyl bioisostere in medicinal chemistry, but efficient synthesis of β-gem-difluoroalkene esters remains challenging so far. Herein, we disclose a photoredox-catalyzed allylic defluorinative alkoxycarbonylation of trifluoromethyl alkenes enabled by intermolecular… read more here.
Keywords: allylic defluorinative; defluorinative alkoxycarbonylation; alkoxycarbonylation trifluoromethyl; catalyzed allylic ... See more keywords
Ligand-Free Nickel-Catalyzed Reductive Allylic Defluorinative Cross-Coupling of α-Trifluoromethyl Alkenes with Epoxides
Sign Up to like & getrecommendations! Published in 2020 at "Synlett"
DOI: 10.1055/s-0040-1707170
Abstract: We report a reductive allylic defluorinative reaction of α-trifluoromethyl alkenes with terminal epoxides, which consists of an iodide-mediated regioselective ring opening and a nickel-catalyzed radical-type cross-coupling, providing diverse tertiary gem-difluorobishomoallylic alcohols in moderate to high… read more here.
Keywords: trifluoromethyl alkenes; allylic defluorinative; reductive allylic; nickel catalyzed ... See more keywords