Aloe emodin relieves Ang II‐induced endothelial junction dysfunction via promoting ubiquitination mediated NLRP3 inflammasome inactivation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ma0520-582r
Abstract: Recent studies have revealed that aloe emodin (AE), a natural compound from the root and rhizome of Rheum palmatum L., exhibits significant pharmacologic activities. However, the pharmacologic relevance of the compound, particularly for cardiovascular disease,… read more here.
Keywords: activation; microscopy; ubiquitination; nlrp3 inflammasome ... See more keywords
Molecular docking and muiltple spectroscopy investigation on the binding characteristics of aloe-emodin to pepsin
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.05.084
Abstract: Abstract In this study, the binding characteristics of aloe-emodin (AE) and pepsin were investigated via multiple spectroscopic and molecular docking methods. The Stern-Volmer quenching constant (Ksv) suggested that AE quenched the fluorescence intensity of pepsin… read more here.
Keywords: pepsin; characteristics aloe; spectroscopy; emodin pepsin ... See more keywords
Extraction of phenolic components from an Aloe vera (Aloe barbadensis Miller) crop and their potential as antimicrobials and textile dyes
Sign Up to like & getrecommendations! Published in 2019 at "Sustainable Chemistry and Pharmacy"
DOI: 10.1016/j.scp.2019.100168
Abstract: Abstract The present work focuses on the use of solid and agricultural residues from Aloe vera crops, as a source of antimicrobial agents and textile dyes. The roots from an A. vera plantation post-harvest were… read more here.
Keywords: aloe emodin; textile dyes; aloe vera; phenolic components ... See more keywords
Gamma irradiation of aloe-emodin induced structural modification and apoptosis through a ROS- and caspase-dependent mitochondrial pathway in stomach tumor cells
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2018.1440330
Abstract: Abstract Purpose: The changes in molecular structure and the physiological properties of a gamma-irradiated aloe-emodin were examined. Materials and methods: Aloe-emodin was gamma-irradiated at doses ranging from 0 to 150 kGy, and the molecular structure… read more here.
Keywords: aloe emodin; gamma irradiation; emodin; gamma irradiated ... See more keywords
Design, synthesis, cytotoxic, and anti-inflammatory activities of some novel analogues of aloe-emodin isolated from the rhizomes of Rheum emodi
Sign Up to like & getrecommendations! Published in 2022 at "Natural Product Research"
DOI: 10.1080/14786419.2021.2024531
Abstract: Abstract In connection with our continuous efforts in the synthesis of derivatives from major compounds isolated from traditional medicinal plants, in the present study we have attempted to synthesize the furan-conjugated aloe-emodin derivatives (5a–j) using… read more here.
Keywords: design synthesis; aloe emodin; cytotoxic anti; anti inflammatory ... See more keywords
Development of a Colloidal Gold Immunochromatographic Strip for the One-Step Evaluation of the Total Content of Rhein and Aloe-Emodin in Rhubarb
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Analytical Chemistry"
DOI: 10.1155/2022/7067245
Abstract: In this study, a colloidal gold immunochromatographic strip was developed for simultaneous detection of rhein and aloe-emodin in rhubarb. The cutoff value, defined as the lowest concentration for which the test line was invisible on… read more here.
Keywords: rhein aloe; aloe emodin; gold immunochromatographic; strip ... See more keywords
Advances in Understanding the Role of Aloe Emodin and Targeted Drug Delivery Systems in Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7928200
Abstract: Cancer is one of the important causes of death worldwide. Despite remarkable improvements in cancer research in the past few decades, several cancer patients still cannot be cured owing to the development of drug resistance.… read more here.
Keywords: drug delivery; delivery systems; cancer; aloe emodin ... See more keywords
Antiplasmodial potential and quantification of aloin and aloe-emodin in Aloe vera collected from different climatic regions of India
Sign Up to like & getrecommendations! Published in 2017 at "BMC Complementary and Alternative Medicine"
DOI: 10.1186/s12906-017-1883-0
Abstract: BackgroundIn this study, Aloe vera samples were collected from different climatic regions of India. Quantitative HPTLC (high performance thin layer chromatography) analysis of important anthraquinones aloin and aloe-emodin and antiplasmodial activity of crude aqueous extracts… read more here.
Keywords: aloe emodin; aloin aloe; aloe vera; antiplasmodial potential ... See more keywords
Induction of Mitotic Catastrophe in Human Cervical Cancer Cells After Administration of Aloe-emodin.
Sign Up to like & getrecommendations! Published in 2018 at "Anticancer research"
DOI: 10.21873/anticanres.12443
Abstract: BACKGROUND Aloe-emodin is an anthraquinone with potential pharmacological properties, including numerous antitumor properties. The purpose of the study was to determine whether aloe-emodin induces mitotic death in cervical cancer cells. MATERIALS AND METHODS Analysis of… read more here.
Keywords: aloe emodin; mitotic catastrophe; cervical cancer; cancer cells ... See more keywords
Aloe-Emodin Induces Mitochondrial Dysfunction and Pyroptosis by Activation of the Caspase-9/3/Gasdermin E Axis in HeLa Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.854526
Abstract: Aloe-emodin (1,8-dihydroxy-3-hydroxymethyl-anthraquinone), derived from some Chinese edible medicinal herbs, exerts a potential anticancer activity on various cancer cells, making it a drug candidate for cancer therapy. Yet, the role of aloe-emodin in pyroptosis, a new… read more here.
Keywords: aloe emodin; hela cells; pyroptosis; mitochondrial dysfunction ... See more keywords
The Comparison of the Efficiency of Emodin and Aloe-Emodin in Photodynamic Therapy
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23116276
Abstract: Skin cancer (melanoma and non-melanoma) is the most frequent type of malignancy in the Caucasian population. Photodynamic therapy (PDT) as an interesting and unique strategy may potentially boost standard therapeutic approaches. In the present study,… read more here.
Keywords: aloe emodin; photodynamic therapy; cell; emodin aloe ... See more keywords