Alogliptin alleviates liver fibrosis via suppression of activated hepatic stellate cell.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.02.065
Abstract: Liver fibrosis occurs in most types of chronic liver diseases. The understanding of the pathogenesis of liver fibrosis has grown considerably, but the effective treatments are still lacking. Alogliptin, a classical Dipeptidyl peptidase-4 (DPP4) inhibitor… read more here.
Keywords: stellate cell; fibrosis; liver fibrosis; alogliptin ... See more keywords
The anti-diabetic drug alogliptin induces vasorelaxation via activation of Kv channels and SERCA pumps.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.173991
Abstract: In the present study, we investigated the vasorelaxant effects of alogliptin, an oral antidiabetic drug in the dipeptidyl peptidase-4 (DPP-4) inhibitor class, using phenylephrine (Phe)-induced pre-contracted aortic rings. Alogliptin induced vasorelaxation in a dose-dependent manner.… read more here.
Keywords: channel inhibitor; inhibitor; vasorelaxation; alogliptin ... See more keywords
Alogliptin improves endothelial function by promoting autophagy in perivascular adipose tissue of obese mice through a GLP-1-dependent mechanism.
Sign Up to like & getrecommendations! Published in 2019 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2018.11.003
Abstract: OBJECTIVE Perivascular adipose tissue (PVAT) regulates vascular function in a paracrine manner and the vasodilatory effect of PVAT on vessels is completely abolished in obesity. In addition, autophagy is required for maintaining biological function of… read more here.
Keywords: alogliptin; endothelial function; obese mice; function ... See more keywords
Alogliptin Induced Stomatitis: An Adverse Drug Event Case Report.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmacy practice"
DOI: 10.1177/08971900221108721
Abstract: Background: Dipeptidyl peptidase (DPP)-4 inhibitors are commonly used agents to treat type 2 diabetes mellitus (T2DM). Although generally well tolerated, stomatitis has been previously reported as an adverse event with sitagliptin and linagliptin. Stomatitis with… read more here.
Keywords: alogliptin; event; stomatitis; report ... See more keywords
Alogliptin and Heart Failure Outcomes in Patients With Type 2 Diabetes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmacy practice"
DOI: 10.1177/08971900221135656
Abstract: Background: In 2016, the FDA issued a warning for saxagliptin and alogliptin regarding an increased risk of heart failure (HF), potentially limiting the use of effective medications in type 2 diabetes. Current data and guideline… read more here.
Keywords: alogliptin; heart failure; type diabetes; risk ... See more keywords
Alogliptin after acute coronary syndrome in patients with type 2 diabetes: a renal function stratified analysis of the EXAMINE trial
Sign Up to like & getrecommendations! Published in 2020 at "BMC Medicine"
DOI: 10.1186/s12916-020-01616-8
Abstract: Background The EXAMINE trial tested the efficacy and safety of alogliptin, an inhibitor of dipeptidyl peptidase 4, compared with placebo in 5380 patients with type 2 diabetes and a recent acute coronary syndrome. Because alogliptin… read more here.
Keywords: alogliptin; egfr; patients type; type diabetes ... See more keywords
Investigation of Alogliptin-Loaded In Situ Gel Implants by 23 Factorial Design with Glycemic Assessment in Rats
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14091867
Abstract: The aim of the study was to design injectable long-acting poly (lactide-co-glycolide) (PLGA)-based in situ gel implants (ISGI) loaded with the anti-diabetic alogliptin. Providing sustained therapeutic exposures and improving the pharmacological responses of alogliptin were… read more here.
Keywords: factorial design; alogliptin; alogliptin loaded; situ gel ... See more keywords