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Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b05796
Abstract: De novo biocatalysts have been successfully generated by computational design and subsequent experimental optimization. Here, we examined the evolutionary history of the computationally designed (retro-)aldolase RA95. The modest activity of the starting enzyme was previously…
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Keywords:
mechanism;
designed retro;
retro aldolase;
computationally designed ... See more keywords