ALOX12 inhibition sensitizes breast cancer to chemotherapy via AMPK activation and inhibition of lipid synthesis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.101
Abstract: Arachidonate lipoxygenase12 (Alox12) and its metabolites 12S-hydroxyeicosatetraenoic acid (12S-HETE) have been implicated in influencing tumor transformation and progression. In this study, we have systematically evaluated the expression, function and the downstream effectors of Alox12 in… read more here.
Keywords: alox12; lipid synthesis; inhibition; breast cancer ... See more keywords
ALOX12 is required for p53-mediated tumor suppression through a distinct ferroptosis pathway
Sign Up to like & getrecommendations! Published in 2019 at "Nature cell biology"
DOI: 10.1038/s41556-019-0305-6
Abstract: It is well established that ferroptosis is primarily controlled by glutathione peroxidase 4 (GPX4). Surprisingly, we observed that p53 activation modulates ferroptotic responses without apparent effects on GPX4 function. Instead, ALOX12 inactivation diminishes p53-mediated ferroptosis… read more here.
Keywords: alox12; suppression; ferroptosis pathway; p53 mediated ... See more keywords