NOVEL ALPHA-ACTININ 2 MUTATIONS ARE ASSOCIATED WITH CARDIOMYOPATHY AND HYPERTROPHY IN HUMAN CARDIAC TISSUE AND IPSC-DERIVED CARDIOMYOCYTES
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(19)31634-1
Abstract: In cardiac and skeletal muscle, alpha-actinins are critical cytoskeletal proteins that anchor actin filaments within the sarcomere. Mutations in ACTN2 have been associated with cardiac abnormalities, including arrhythmias, hypertrophic and dilated cardiomyopathies. However, the mechanisms… read more here.
Keywords: cardiomyopathy hypertrophy; mutations associated; novel alpha; associated cardiomyopathy ... See more keywords
Reciprocal regulation of actomyosin organization and contractility in nonmuscle cells by tropomyosins and alpha-actinins
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e19-02-0082
Abstract: Contractile arrays of actin and myosin II filaments drive many essential processes in nonmuscle cells, including migration and adhesion. Sequential organization of actin and myosin along one dimension is followed by expansion into a two-dimensional… read more here.
Keywords: actomyosin; organization; stack formation; alpha actinin ... See more keywords
Abstract 910: Identification of Novel Cardiac Sarcomere Interactions Using BioID Proximity-labeling
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.910
Abstract: Mutations in components of the sarcomere, the contractile unit of cardiomyocytes, are a leading cause of genetic cardiomyopathies, such as dilated cardiomyopathy (DCM), which is an important contributor to heart failure burden. Using human induced… read more here.
Keywords: abstract 910; proximity labeling; 910 identification; bioid proximity ... See more keywords
Alpha-actinin 4 and tumorigenesis of hepatocellular carcinoma
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DOI: 10.21037/31073
Abstract: Background: We examined the expression of alpha-actinin 4 (ACTN4) in hepatocellular carcinoma (HCC) tissues, to investigate the relationships between the expression of ACTN4 and the clinicopathological features of HCC patients. We have also analyzed the… read more here.
Keywords: hepatocellular carcinoma; alpha actinin; expression; hcc patients ... See more keywords
Alpha-actinin 4 and tumorigenesis of hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Translational Cancer Research"
DOI: 10.21037/tcr.2019.07.34
Abstract: Background We examined the expression of alpha-actinin 4 (ACTN4) in hepatocellular carcinoma (HCC) tissues, to investigate the relationships between the expression of ACTN4 and the clinicopathological features of HCC patients. We have also analyzed the… read more here.
Keywords: hepatocellular carcinoma; alpha actinin; expression; hcc patients ... See more keywords
Characterization and Function of the Interaction of Angiogenin With Alpha-Actinin 2
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DOI: 10.3389/fmolb.2022.837971
Abstract: Angiogenin (ANG) is the first human tumor-derived angiogenic protein, which can promote angiogenesis and tumor growth. In a previous study, we identified alpha-actinin 2 (ACTN2), a cytoskeletal protein, as a direct interacting protein with angiogenin.… read more here.
Keywords: interaction; alpha actinin; actn2; angiogenin ... See more keywords