Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-057460
Abstract: Introduction Postoperative delirium is common in older cardiac surgery patients and associated with negative short-term and long-term outcomes. The alpha-2-adrenergic receptor agonist dexmedetomidine shows promise as prophylaxis and treatment for delirium in intensive care units… read more here.
Keywords: surgery; trial; delirium; alpha adrenergic ... See more keywords
Central alpha-2 adrenergic mechanisms affect human sympathetic neuronal discharge strategies
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DOI: 10.1152/physiol.2023.38.s1.5733156
Abstract: The central neural mechanisms affecting sympathetic neuronal discharge strategies supporting homeostatic adjustments in human muscle sympathetic nerve activity (MSNA) remain unclear. This study investigated the hypothesis that central alpha-2 adrenergic mechanisms affect sympathetic action potential… read more here.
Keywords: condition; control; alpha adrenergic; physiology ... See more keywords
The Association Between Alpha-1 Adrenergic Receptor Antagonists and In-Hospital Mortality From COVID-19
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DOI: 10.3389/fmed.2021.637647
Abstract: Effective therapies for coronavirus disease 2019 (COVID-19) are urgently needed, and pre-clinical data suggest alpha-1 adrenergic receptor antagonists (α1-AR antagonists) may be effective in reducing mortality related to hyperinflammation independent of etiology. Using a retrospective… read more here.
Keywords: alpha adrenergic; mortality; association; covid ... See more keywords
The Association of an Alpha-2 Adrenergic Receptor Agonist and Mortality in Patients With COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.797647
Abstract: There is a need for treatments to reduce coronavirus disease 2019 (COVID-19) mortality. Alpha-2 adrenergic receptor (α2 AR) agonists can dampen immune cell and inflammatory responses as well as improve oxygenation through physiologic respiratory parameters.… read more here.
Keywords: dex; mortality; alpha adrenergic; day mortality ... See more keywords