Evaluation of the genotoxicity of alpha‐amanitin in mice bone marrow cells
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DOI: 10.1016/j.toxicon.2017.07.005
Abstract: ABSTRACT Alpha‐amanitin is a known cytotoxic substance found in some mushroom species including Amanita phalloides. Its main mechanism of action is to block the transcription, which can lead to cell death. Lack of reports on… read more here.
Keywords: amanitin; agr amanitin; alpha amanitin; marrow cells ... See more keywords
Characterization of the RAS/RAF/ERK Signal Cascade as a Novel Regulating Factor in Alpha-Amanitin-Induced Cytotoxicity in Huh-7 Cells
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DOI: 10.3390/ijms232012294
Abstract: The well-known hepatotoxicity mechanism resulting from alpha-amanitin (α-AMA) exposure arises from RNA polymerase II (RNAP II) inhibition. RNAP Ⅱ inhibition occurs through the dysregulation of mRNA synthesis. However, the signaling pathways in hepatocytes that arise… read more here.
Keywords: ama exposure; raf erk; alpha amanitin; huh cells ... See more keywords
Identification of Decrease in TRiC Proteins as Novel Targets of Alpha-Amanitin-Derived Hepatotoxicity by Comparative Proteomic Analysis In Vitro
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DOI: 10.3390/toxins13030197
Abstract: Alpha-amanitin (α-AMA) is a cyclic peptide and one of the most lethal mushroom amatoxins found in Amanita phalloides. α-AMA is known to cause hepatotoxicity through RNA polymerase II inhibition, which acts in RNA and DNA… read more here.
Keywords: identification decrease; analysis; tric proteins; hepatotoxicity ... See more keywords