Co‐expression of alpha‐1 antitrypsin with cytoplasmic domain of v‐SNARE in Pichia pastoris: Preserving biological activity of alpha‐1 antitrypsin
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1578
Abstract: Alpha‐1‐antitrypsin (A1AT) is a major serum protein in human with protease inhibitory activity. Because of its extensive application in medicine, recombinant DNA technology has been considered for its production. The current study examines coexpression of… read more here.
Keywords: biological activity; domain snare; cytoplasmic domain; alpha antitrypsin ... See more keywords
High‐level production of wild‐type and oxidation‐resistant recombinant alpha‐1‐antitrypsin in glycoengineered CHO cells
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28129
Abstract: Alpha‐1‐antitrypsin (A1AT) is a serine protease inhibitor which blocks the activity of serum proteases including neutrophil elastase to protect the lungs. Its deficiency is known to increase the risk of pulmonary emphysema as well as… read more here.
Keywords: oxidation; alpha antitrypsin; a1at; cho cells ... See more keywords
Alpha‐1 Antitrypsin Deficiency Liver Disease, Mutational Homogeneity Modulated by Epigenetic Heterogeneity With Links to Obesity
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30526
Abstract: Alpha‐1 antitrypsin deficiency (AATD) liver disease is characterized by marked heterogeneity in presentation and progression, despite a common underlying gene mutation, strongly suggesting the involvement of other genetic and/or epigenetic modifiers. Variation in clinical phenotype… read more here.
Keywords: heterogeneity; alpha antitrypsin; aatd; disease ... See more keywords
Hyperpolarized 3He MRI ventilatory apparent diffusion coefficient of alpha‐1 antitrypsin deficiency
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.26202
Abstract: Alpha-1 antitrypsin deficiency (AATD) leads to disabling chronic obstructive pulmonary disease (COPD). Current therapy aimed at slowing lung disease progression includes exogenous alpha-1 antitrypsin augmentation therapy, but there are few potential new treatments under development.… read more here.
Keywords: diffusion; time; alpha antitrypsin; mri ... See more keywords
Measuring the Effect of Histone Deacetylase Inhibitors (HDACi) on the Secretion and Activity of Alpha-1 Antitrypsin.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7163-3_18
Abstract: Alpha-1 antitrypsin deficiency (AATD) is a protein conformational disease with the most common cause being the Z-variant mutation in alpha-1 antitrypsin (Z-AAT). The misfolded conformation triggered by the Z-variant disrupts cellular proteostasis (protein folding) systems… read more here.
Keywords: secretion; antitrypsin; alpha antitrypsin; histone deacetylase ... See more keywords
Therapeutics: Alpha-1 Antitrypsin Augmentation Therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7163-3_25
Abstract: Subjects with alpha-1 antitrypsin deficiency who develop pulmonary disease are managed following general treatment guidelines, including disease management interventions. In addition, administration of intravenous infusions of alpha-1 proteinase inhibitor (augmentation therapy) at regular schedules is… read more here.
Keywords: alpha antitrypsin; therapeutics alpha; therapy; augmentation therapy ... See more keywords
Practical Methods for Assessing Emphysema Severity Based on Estimation of Linear Mean Intercept (Lm) in the Context of Animal Models of Alpha-1 Antitrypsin Deficiency.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7163-3_9
Abstract: Alpha-1 antitrypsin deficiency is typified by panacinar emphysema in humans. Whilst animal models of (α1A-TD) that more accurately reflect the histology and molecular pathology of α1A-TD are in development, it is timely to discuss methods… read more here.
Keywords: emphysema severity; linear mean; alpha antitrypsin; severity ... See more keywords
An integrative analysis to distinguish between emphysema (EML) and alpha-1 antitrypsin deficiency-related emphysema (ADL)-A systems biology approach.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in protein chemistry and structural biology"
DOI: 10.1016/bs.apcsb.2021.02.004
Abstract: Lung Emphysema is an abnormal enlargement of the air sacs followed by the destruction of alveolar walls without any prominent fibrosis. This study primarily identifies the differentially expressed genes (DEGs), interactions between them, and their… read more here.
Keywords: biology; antitrypsin deficiency; deficiency related; emphysema ... See more keywords
Alpha-1 antitrypsin deficiency: From the lung to the heart?
Sign Up to like & getrecommendations! Published in 2018 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2018.01.042
Abstract: BACKGROUND AND AIMS Alpha-1 antitrypsin (A1AT) is the most abundant serine protease inhibitor in human blood and exerts important anti-inflammatory and immune-modulatory effects. In combination with smoking or other long-term noxious exposures such as occupational… read more here.
Keywords: cimt; alpha antitrypsin; cardiovascular risk; deficiency ... See more keywords
Investigating the link between Alpha-1 Antitrypsin Deficiency and Abdominal Aortic Aneurysms.
Sign Up to like & getrecommendations! Published in 2021 at "Annals of vascular surgery"
DOI: 10.1016/j.avsg.2021.05.064
Abstract: OBJECTIVES Alpha-1-Antitrypsin (AAT) is one of the major plasmatic protease inhibitors. In the last decade, an association between Alpha-1-Antitrypsin Deficiency (AATD) and Abdominal Aortic Aneurysms (AAA) has been hypothesized. Multiple factors may be involved in… read more here.
Keywords: aortic aneurysms; alpha antitrypsin; antitrypsin deficiency; abdominal aortic ... See more keywords
A robust feeding control strategy adjusted and optimized by a neural network for enhancing of alpha 1-antitrypsin production in Pichia pastoris
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Engineering Journal"
DOI: 10.1016/j.bej.2019.01.005
Abstract: Abstract Exact monitoring of the key process variables, such as specific growth rate (μ), is essential for effective process control, and maintenance of the optimal conditions for the production of recombinant proteins. In this study,… read more here.
Keywords: neural network; pichia pastoris; control; strategy ... See more keywords