Glucose controls glucagon secretion by directly modulating cAMP in alpha cells
Sign Up to like & getrecommendations! Published in 2019 at "Diabetologia"
DOI: 10.1007/s00125-019-4857-6
Abstract: Aims/hypothesisGlucagon is critical for normal glucose homeostasis and aberrant secretion of the hormone aggravates dysregulated glucose control in diabetes. However, the mechanisms by which glucose controls glucagon secretion from pancreatic alpha cells remain elusive. The… read more here.
Keywords: glucagon secretion; secretion; camp; alpha cells ... See more keywords
IL-6 is present in beta and alpha cells in human pancreatic islets: Expression is reduced in subjects with type 1 diabetes.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical immunology"
DOI: 10.1016/j.clim.2019.108320
Abstract: IL-6 is a pro-inflammatory cytokine upregulated in some autoimmune diseases. The role of IL-6 in the development of type 1 diabetes (T1D) is unclear. Clinical studies are investigating whether tocilizumab (anti-IL-6 receptor) can help preserve… read more here.
Keywords: beta alpha; beta; type diabetes; expression ... See more keywords
A method for the generation of human stem cell-derived alpha cells
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16049-3
Abstract: The generation of pancreatic cell types from renewable cell sources holds promise for cell replacement therapies for diabetes. Although most effort has focused on generating pancreatic beta cells, considerable evidence indicates that glucagon secreting alpha… read more here.
Keywords: stem cell; cell; cell derived; alpha cells ... See more keywords
Elevated Levels of Alpha Cells Emanating from the Pancreatic Ducts of a Patient with a Low BMI and Chronic Pancreatitis
Sign Up to like & getrecommendations! Published in 2018 at "Cell Transplantation"
DOI: 10.1177/0963689718755707
Abstract: Chronic pancreatitis (CP) is an inflammatory disease that causes progressive damage to the pancreatic parenchyma with irreversible morphological changes and fibrotic replacement of the gland. The risk factors associated with developing CP have been described… read more here.
Keywords: elevated levels; pancreatitis; chronic pancreatitis; alpha cells ... See more keywords
Pancreatic Alpha-Cells Contribute Together With Beta-Cells to CXCL10 Expression in Type 1 Diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.00630
Abstract: C-X-C Motif Chemokine Ligand 10 (CXCL10) is a pro-inflammatory chemokine specifically recognized by the ligand receptor CXCR3 which is mostly expressed in T-lymphocytes. Although CXCL10 expression and secretion have been widely associated to pancreatic islets… read more here.
Keywords: cxcl10 expression; expression; mice; alpha cells ... See more keywords
Modeling the Amino Acid Effect on Glucagon Secretion from Pancreatic Alpha Cells
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12040348
Abstract: Type 2 Diabetes Mellitus (T2DM) is a burdensome problem in modern society, and intensive research is focused on better understanding the underlying cellular mechanisms of hormone secretion for blood glucose regulation. T2DM is a bi-hormonal… read more here.
Keywords: pancreatic alpha; alpha cells; secretion; amino acid ... See more keywords