Diagnostic accuracy of alpha-defensin in periprosthetic joint infection: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2017 at "International Orthopaedics"
DOI: 10.1007/s00264-017-3647-3
Abstract: BackgroundAlpha-defensin, a novel biomarker, has shown great potential for the accurate diagnosis of periprosthetic joint infection (PJI) in recent years: many published studies have presented encouraging results. Nevertheless, the diagnostic accuracy of alpha-defensin is inconsistent… read more here.
Keywords: defensin; analysis; diagnostic accuracy; joint infection ... See more keywords
Current Recommendations for the Diagnosis of Acute and Chronic PJI for Hip and Knee—Cell Counts, Alpha-Defensin, Leukocyte Esterase, Next-generation Sequencing
Sign Up to like & getrecommendations! Published in 2018 at "Current Reviews in Musculoskeletal Medicine"
DOI: 10.1007/s12178-018-9513-0
Abstract: Purpose of ReviewDespite significant progress in recent years, the diagnosis of periprosthetic joint infection (PJI) remains a challenge and no gold standard test exists. A combination of serological, synovial, microbiological, histological, and radiological investigations is… read more here.
Keywords: current recommendations; generation sequencing; pji; hip knee ... See more keywords
Alpha defensin-1 attenuates surgically induced osteoarthritis in association with promoting M1 to M2 macrophage polarization.
Sign Up to like & getrecommendations! Published in 2021 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2021.04.006
Abstract: OBJECTIVE Macrophages play an important part in the pathogenesis of osteoarthritis (OA). Our objective was to determine the effects of α-defensin-1 on macrophage polarization and consequently OA. METHODS OA synovial tissue and synovial fluid were… read more here.
Keywords: defensin; macrophage polarization; polarization; defensin attenuates ... See more keywords
Alpha defensin, leukocyte esterase, C-reactive protein, and leukocyte count in synovial fluid for pre-operative diagnosis of periprosthetic infection
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Immunopathology and Pharmacology"
DOI: 10.1177/2058738418806072
Abstract: Synovial fluid analysis for diagnosis of prosthetic joint infections has gained increasing interest in the recent past when markers more specific for these infections than the serum ones have been identified. Despite the important steps… read more here.
Keywords: leukocyte; alpha defensin; leukocyte esterase; diagnosis ... See more keywords
Alpha-defensin-dependent enhancement of enteric viral infection
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DOI: 10.1371/journal.ppat.1006446
Abstract: The small intestinal epithelium produces numerous antimicrobial peptides and proteins, including abundant enteric α-defensins. Although they most commonly function as potent antivirals in cell culture, enteric α-defensins have also been shown to enhance some viral… read more here.
Keywords: defensin; enteric defensins; infection; defensin dependent ... See more keywords
Human Neutrophil α-Defensins 1–3 Are Upregulated in the Microenvironment of Fibrotic Liver
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DOI: 10.3390/medicina59030496
Abstract: Background and Objectives: Neutrophil infiltration is an established signature of Non-Alcoholic Fatty Liver Disease (NAFLD) and Steatohepatitis (NASH). The most abundant neutrophilic peptide, alpha-defensin, is considered a new evolving risk factor in the inflammatory milieu,… read more here.
Keywords: alpha defensin; human neutrophil; fibrosis; risk ... See more keywords