Alpha-Emitters and Targeted Alpha Therapy in Oncology: from Basic Science to Clinical Investigations
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DOI: 10.1007/s11523-018-0550-9
Abstract: Alpha-emitters are radionuclides that decay through the emission of high linear energy transfer α-particles and possess favorable pharmacologic profiles for cancer treatment. When coupled with monoclonal antibodies, peptides, small molecules, or nanoparticles, the excellent cytotoxic… read more here.
Keywords: emitters targeted; alpha therapy; targeted alpha; therapy ... See more keywords
Radiopharmaceuticals Based on Alpha Emitters: Preparation, Properties, and Application
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DOI: 10.1134/s1063778818100071
Abstract: In this review, the problems of the development of radiopharmaceuticals (RPs) based on alphaemitting radionuclides are discussed. The prospects of application of the radionuclides 227Th, 225Ac, 223Ra, 213Bi, 212Pb/212Bi, 212Bi, 211At, and 149Tb are estimated… read more here.
Keywords: radiopharmaceuticals based; based alpha; properties application; emitters preparation ... See more keywords
Radium and other alpha emitters in prostate cancer
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DOI: 10.21037/tau.2018.02.07
Abstract: 223Radium (223Ra) is the first alpha-emitting therapy proven effective in human cancer. Prospective randomized trials indicate that 223Ra, which concentrates after intravenous injection in areas of osteoblastic metastatic disease, can prolong survival in bone-dominant castrate… read more here.
Keywords: radium alpha; prostate cancer; emitters prostate; cancer ... See more keywords