Alpha‐globin gene mutation spectrum in patients with microcytic hypochromic anemia from Mazandaran Province, Iran
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23018
Abstract: It is estimated about 7% of the world population is carriers of hemoglobin diseases. Alpha‐thalassemia is one of the most common hereditary hemoglobin disorders in the world. This study investigated alpha‐globin mutations in potential carriers… read more here.
Keywords: anemia mazandaran; gene mutation; globin gene; alpha globin ... See more keywords
Genotype–phenotype correlation in patients with deletional and nondeletional mutations of Hb H disease in Southwest of Iran
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-08986-4
Abstract: We studied the alpha-globin gene genotypes, hematologic values, and transfusion-dependence of patients with Hb H disease. Molecular characterization of alpha-thalassemia was performed. We identified 120 patients with Hb H disease. Of these patients, 35 (29.16%)… read more here.
Keywords: form; phenotype correlation; alpha globin; patients deletional ... See more keywords
Investigating Zeta Globin Gene Expression to Develop a Potential Therapy for Alpha Thalassemia Major
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DOI: 10.1182/blood-2020-142922
Abstract: Introduction: Alpha globin mutations are very common worldwide, and the severity of resulting anemia depends on the number and type of mutated alleles. While the 4 gene mutation (alpha thalassemia major, ATM) was previously deemed… read more here.
Keywords: alpha globin; expression; globin; zeta globin ... See more keywords
Alpha globin gene copy number and hypertension risk among Black Americans
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DOI: 10.1371/journal.pone.0271031
Abstract: BACKGROUND: Alpha globin is expressed in the endothelial cells of human resistance arteries where it binds to endothelial nitric oxide synthase and limits release of the vasodilator nitric oxide. Genomic deletion of the alpha globin… read more here.
Keywords: alpha globin; risk; copy number; hypertension ... See more keywords