Pancreatic lipase and alpha-glucosidase inhibitors screening from Schisandra chinensis based on spectrum-effect relationship and ultra- high-performance liquid chromatography-tandem mass spectrometry.
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DOI: 10.1002/jssc.202200541
Abstract: As a traditional Chinese medicine, Schisandra chinensis has potential weight-loss effect by delaying carbohydrate absorption and improving lipid metabolic disorders. However, its active components are still unclear and require in-depth research. In this study, the… read more here.
Keywords: performance liquid; alpha glucosidase; schisandra chinensis; liquid chromatography ... See more keywords
A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes
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DOI: 10.1007/s11101-021-09773-1
Abstract: Diabetes mellitus is a multifactorial global health disorder that is rising at an alarming rate. Cardiovascular diseases, kidney damage and neuropathy are the main cause of high mortality rates among individuals with diabetes. One effective… read more here.
Keywords: review alpha; type diabetes; glucosidase; alpha glucosidase ... See more keywords
Alpha-glucosidase inhibitors from Nervilia concolor, Tecoma stans, and Bouea macrophylla
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2021.09.070
Abstract: Abstract Tecoma stans (L.) Juss. Ex Kunth is widely used in folk medicine. In ethnomedicine, it is applied as a cardioprotective, hepatoprotective, antiarthritic, antinociceptive, anti-inflammatory, and antimicrobial. The aqueous extract is considered antidiabetic, and is… read more here.
Keywords: medicine; nervilia concolor; macrophylla; alpha glucosidase ... See more keywords
Alpha glucosidase inhibitory properties of a few bioactive compounds isolated from black rice bran: combined in vitro and in silico evidence supporting the antidiabetic effect of black rice
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DOI: 10.1039/d2ra04228b
Abstract: In view of the recent reports of the antidiabetic effect of the black rice bran extract, an attempt has been made in the present work to evaluate the potential α-glucosidase inhibitory activity of a few… read more here.
Keywords: rice bran; bioactive compounds; alpha glucosidase; rice ... See more keywords
Two new phenolic compounds from Boerhavia erecta collected in Vietnam.
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DOI: 10.1080/14786419.2022.2086543
Abstract: Boerhavia erecta is a tropical plant that is widely used in Asian folk medicine. Little is known about the alpha-glucosidase inhibition and antimicrobial properties of compounds from this plant. In the present study, the phytochemical… read more here.
Keywords: inhibition; alpha glucosidase; erecta collected; collected vietnam ... See more keywords
Antibodies against recombinant human alpha-glucosidase do not seem to affect clinical outcome in childhood onset Pompe disease
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DOI: 10.1186/s13023-022-02175-2
Abstract: Background Enzyme replacement therapy (ERT) with recombinant human alpha-glucosidase (rhGAA, alglucosidase alfa) has improved survival, motor outcomes, daily life activity and quality of life in Pompe patients. However, ERT in Pompe disease often induces formation… read more here.
Keywords: alpha glucosidase; antibody titers; antibody; human alpha ... See more keywords
THE EVALUATION OF NORMO-GLYCEMIC AND CYTO-REGENERATIVE EFFECTS OF PELARGONIUM SPECIES EXTRACTS
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DOI: 10.31925/farmacia.2020.1.19
Abstract: Alpha-amylase and alpha-glucosidase are enzymes that modulate the chain breaking process of alpha-linked polysaccharides with an impact on promoting postprandial hyperglycaemia. Pancreatic alpha-amylase is an enzyme that catalyses the hydrolysis of starch and glycogen, yielding… read more here.
Keywords: pelargonium species; alpha amylase; alpha glucosidase; evaluation normo ... See more keywords
Bioreactor-grown exo- and endo-β-glucan from Malaysian Ganoderma lucidum: An in vitro and in vivo study for potential antidiabetic treatment
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DOI: 10.3389/fbioe.2022.960320
Abstract: This study aims to identify the roles of exo-β-glucan (EPS-BG) and endo-β-glucan (ENS-BG) extracted from Ganoderma lucidum (GL) in inhibiting the alpha-glucosidase enzyme, a target mechanism for postprandial hyperglycaemia regulation. Upscale production of GL was… read more here.
Keywords: alpha glucosidase; endo glucan; ganoderma lucidum; eps ens ... See more keywords
Immune transgene-dependent myocarditis in macaques after systemic administration of adeno-associated virus expressing human acid alpha-glucosidase
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1094279
Abstract: Immune responses to human non-self transgenes can present challenges in preclinical studies of adeno-associated virus (AAV) gene therapy candidates in nonhuman primates. Although anti-transgene immune responses are usually mild and non-adverse, they can confound pharmacological… read more here.
Keywords: human acid; acid alpha; alpha glucosidase; associated virus ... See more keywords
Liver-related long-term outcomes of alpha-glucosidase inhibitors in patients with diabetes and liver cirrhosis
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DOI: 10.3389/fphar.2022.1049094
Abstract: Background: Adequate management of diabetes in patients with liver cirrhosis can be challenging. We conducted this study to investigate the liver-related long term outcomes of alpha-glucosidase inhibitors (AGIs) in patients with diabetes and cirrhosis. Methods:… read more here.
Keywords: glucosidase inhibitor; liver cirrhosis; alpha glucosidase; glucosidase inhibitors ... See more keywords
Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities, Molecular Docking, and Antioxidant Capacities of Plectranthus ecklonii Constituents
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DOI: 10.3390/antiox11020378
Abstract: Shortage in insulin secretion or degradation of produced insulin is the principal characteristic of the metabolic disorder of diabetes mellitus (DM). However, because the current medications for the treatment of DM have many detrimental side… read more here.
Keywords: alpha amylase; alpha glucosidase; glucosidase; inhibitory ... See more keywords