Protein‐Protein Interaction and Conformational Change in the Alpha‐Helical Membrane Transporter BtuCD‐F in the Native Cellular Envelope
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DOI: 10.1002/cbic.202400858
Abstract: Alpha‐helical membrane proteins perform numerous critical functions essential for the survival of living organisms. Traditionally, these proteins are extracted from membranes using detergent solubilization and reconstitution into liposomes or nanodiscs. However, these processes often obscure… read more here.
Keywords: alpha helical; protein; protein protein; helical membrane ... See more keywords
Probing the competitive inhibitor efficacy of frog-skin alpha helical AMPs identified against ACE2 binding to SARS-CoV-2 S1 spike protein as therapeutic scaffold to prevent COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-022-05117-8
Abstract: In COVID-19 infection, the SARS-CoV-2 spike protein S1 interacts to the ACE2 receptor of human host, instigating the viral infection. To examine the competitive inhibitor efficacy of broad spectrum alpha helical AMPs extracted from frog… read more here.
Keywords: cov spike; spike protein; sars cov; dermaseptin ... See more keywords
Histidine-Covalent Stapled Alpha-Helical Peptides Targeting hMcl-1
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.4c00277
Abstract: Several novel and effective cysteine targeting (Cys) covalent drugs are in clinical use. However, the target area containing a druggable Cys residue is limited. Therefore, methods for creating covalent drugs that target different residues are… read more here.
Keywords: covalent stapled; covalent; alpha helical; histidine covalent ... See more keywords
Soliton excitations and interaction in alpha helical protein with interspine coupling in modified nonlinear Schrödinger equation
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DOI: 10.1088/1674-1056/ab5188
Abstract: In this paper, the three-coupling modified nonlinear Schrödinger (MNLS) equation with variable-coefficients is used to describe the dynamics of soliton in alpha helical protein. This MNLS equation with variable-coefficients is firstly transformed to the MNLS… read more here.
Keywords: helical protein; mnls equation; soliton; alpha helical ... See more keywords
Methods to study folding of alpha-helical membrane proteins in lipids
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DOI: 10.1098/rsob.220054
Abstract: How alpha-helical membrane proteins fold correctly in the highly hydrophobic membrane interior is not well understood. Their folding is known to be highly influenced by the lipids within the surrounding bilayer, but the majority of… read more here.
Keywords: membrane proteins; helical membrane; folding methods; study folding ... See more keywords
Cell-Free Expression to Probe Co-Translational Insertion of an Alpha Helical Membrane Protein
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.795212
Abstract: The majority of alpha helical membrane proteins fold co-translationally during their synthesis on the ribosome. In contrast, most mechanistic folding studies address refolding of full-length proteins from artificially induced denatured states that are far removed… read more here.
Keywords: topology; cell free; helical membrane; alpha helical ... See more keywords
Hydrophobic Alpha-Helical Short Peptides in Overlapping Reading Frames of the Coronavirus Genome
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DOI: 10.3390/pathogens11080877
Abstract: In this study, we show that the coronavirus (CoV) genome may encode many functional hydrophobic alpha-helical peptides (HAHPs) in overlapping reading frames of major coronaviral proteins throughout the entire viral genome. These HAHPs can theoretically… read more here.
Keywords: reading frames; overlapping reading; genome; alpha helical ... See more keywords