The neuroprotective effects of alpha‐lipoic acid on an experimental model of Alzheimer's disease in PC12 cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4213
Abstract: With the growth of the aging population, the prevalence of Alzheimer's disease (AD) has increased and influenced the work and daily life of AD patients, imposing a heavy burden on society and the patients' families.… read more here.
Keywords: pc12 cells; lipoic acid; alpha lipoic; disease ... See more keywords
Neuroprotective evidence of alpha-lipoic acid and desvenlafaxine on memory deficit in a neuroendocrine model of depression
Sign Up to like & getrecommendations! Published in 2018 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-018-1509-1
Abstract: Cognitive impairment is present in patients with depression. We hypothesized that alpha-lipoic acid (ALA) can reduce cognitive impairment, especially when combined to antidepressants. Female mice received vehicle or corticosterone (CORT) 20 mg/kg, s.c. for 14 days. From… read more here.
Keywords: depression; dvs20; cort; alpha lipoic ... See more keywords
Regulation of aging and oxidative stress pathways in aged pancreatic islets using alpha-lipoic acid
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3363-3
Abstract: Oxidative stress has been involved in the aging process and the pathogenesis of type-2 diabetes, which is a serious health problem worldwide. This study investigates the anti-aging, anti-apoptotic, and antioxidant properties of alpha-lipoic acid (ALA),… read more here.
Keywords: oxidative stress; aging oxidative; stress; alpha lipoic ... See more keywords
The protective potential of alpha lipoic acid on amiodarone-induced pulmonary fibrosis and hepatic injury in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-021-04173-7
Abstract: Amiodarone (AMD) is a widely used antiarrhythmic drug prescribed to treat cardiac tachyarrhythmias; however, AMD has been reported to provoke pulmonary fibrosis (PF) and hepatotoxicity. This study aimed to investigate the influence of alpha lipoic… read more here.
Keywords: fibrosis; hepatic injury; pulmonary fibrosis; alpha lipoic ... See more keywords
Protective Effects of Alpha Lipoic Acid Against Arsenic Induced Oxidative Stress in Isolated Rat Liver Mitochondria.
Sign Up to like & getrecommendations! Published in 2021 at "Biological trace element research"
DOI: 10.1007/s12011-021-02712-3
Abstract: Arsenic as a heavy metal and toxic pollutant has been established that has the hepatotoxic effect in animal and human models. Previous studies showed that mitochondria as the first target of arsenic toxicity has a… read more here.
Keywords: induced oxidative; mitochondria; arsenic induced; alpha lipoic ... See more keywords
Alpha Lipoic Acid Supplementation Improves Ovarian Tissue Vitrification Outcome: An Alternative to Preserve the Ovarian Function of Morada Nova Ewe
Sign Up to like & getrecommendations! Published in 2021 at "Reproductive Sciences"
DOI: 10.1007/s43032-021-00593-4
Abstract: This study evaluated the effect of adding alpha lipoic acid (ALA) to the vitrification solution of sheep ovarian tissue on 7 days of in vitro culture or 15 days of xenotransplantion. ALA was used at… read more here.
Keywords: ovarian tissue; tissue; alpha lipoic; culture ... See more keywords
Does alpha‐lipoic acid affect lipid profile? A meta‐analysis and systematic review on randomized controlled trials
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2019.01.001
Abstract: ABSTRACT Randomized controlled trials (RCTs) have demonstrated that alpha lipoic acid (ALA) may change lipid profile, but their results are contradictory. The aim of this study is to conduct a meta‐analysis to assess the effects… read more here.
Keywords: lipid profile; alpha lipoic; profile; lipoic acid ... See more keywords
Characterisation of the binding of dihydro-alpha-lipoic acid to fibrinogen and the effects on fibrinogen oxidation and fibrin formation.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.01.098
Abstract: A reduced form of the alpha-lipoic acid, dihydro-alpha-lipoic acid (DHLA) is a potent, naturally occurring antioxidant which can be consumed as food constituent or as supplement at doses up to 600 mg/day. DHLA has inhibitory effect… read more here.
Keywords: dhla; fibrinogen; lipoic acid; alpha lipoic ... See more keywords
Investigation of alpha-lipoic acid effect on memory impairment considering strain-dependent differences in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119766
Abstract: AIMS Memory impairment is regarded as one of the most challenging neurological disorders. The present study aimed to investigate behavioral and biochemical differences among similar mouse strains following Scopolamine (SCO) exposure as a widespread memory… read more here.
Keywords: sco; memory impairment; alpha lipoic; memory ... See more keywords
Protective effect of alpha-lipoic acid on progression of cataract formation in fructose-induced experimental cataract
Sign Up to like & getrecommendations! Published in 2017 at "PharmaNutrition"
DOI: 10.1016/j.phanu.2017.10.001
Abstract: Abstract Cataract is the leading cause of ocular blindness worldwide and exacerbated by various systemic disorders, including diabetes and hypertension. The present study was designed to investigate the protective effects of alpha-lipoic acid (LA) against… read more here.
Keywords: experimental cataract; induced experimental; fructose induced; cataract ... See more keywords
Diurnal efficacy of alpha-lipoic acid/nifedipine/glimepiride combination mitigates diabetic neuropathies in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Annales pharmaceutiques francaises"
DOI: 10.1016/j.pharma.2021.09.004
Abstract: OBJECTIVES Time-dependent effects of alpha-lipoic acid/nifedipine/glimepiride combination on diabetic neuropathies were investigated in rats. 7 groups (N=9) of rats were used. MATERIALS AND METHODS First and second groups were apparently normal and diabetic rats respectively,… read more here.
Keywords: diabetic neuropathies; nifedipine glimepiride; time; alpha lipoic ... See more keywords