Alpha-2-macroglobulin and heparin cofactor II and the vulnerability of carotid atherosclerotic plaques: An iTRAQ-based analysis.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.042
Abstract: Rupture of carotid atherosclerotic plaque may cause stroke, while few biomarker in clinic can evaluate carotid plaque vulnerability. In this study, we divided the recruited participants into no plaque, stable plaque, and vulnerable plaque group… read more here.
Keywords: vulnerability carotid; carotid atherosclerotic; carotid; vulnerability ... See more keywords
Conformational behavior of alpha-2-macroglobulin: Aggregation and inhibition induced by TFE.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.06.026
Abstract: Alpha-2-macroglobulin (α2M), a pan-proteinase inhibitor, inhibits a variety of endogenous and exogenous proteinases and constitutes an important part of body's innate defense system. In the present study, we explored how trifluoroethanol (TFE) may modulate the… read more here.
Keywords: aggregation; fluorescence; tfe; rayleigh scattering ... See more keywords
Antipsychotic clozapine binding to alpha-2-macroglobulin protects interacting partners against oxidation and preserves the anti-proteinase activity of the protein.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.04.155
Abstract: In this study, the interaction between clozapine, an atypical antipsychotic drug, and alpha-2-macroglobulin (α2M), a multipurpose anti-proteinase, was investigated under simulated (patho) physiological conditions using multiple spectroscopic techniques and molecular modeling. It was found that… read more here.
Keywords: proteinase activity; anti proteinase; clozapine; alpha macroglobulin ... See more keywords
Investigating hydrogen peroxide induced damage to alpha-2-macroglobulin: Biophysical and thermodynamic study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.06.017
Abstract: Abstract Hydrogen peroxide (H 2 O 2 ) is an important signalling molecule and a non-radical reactive oxygen species (ROS) which can convert into more potent oxygen radicals leading to oxidative stress. The correlation between… read more here.
Keywords: spectroscopy; alpha macroglobulin; hydrogen peroxide;
Alpha-2 macroglobulin in Alzheimer’s disease: a marker of neuronal injury through the RCAN1 pathway
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Psychiatry"
DOI: 10.1038/mp.2016.206
Abstract: Preclinical changes that precede the onset of symptoms and eventual diagnosis of Alzheimer’s disease (AD) are a target for potential preventive interventions. A large body of evidence suggests that inflammation is closely associated with AD… read more here.
Keywords: rcan1; alzheimer disease; disease; neuronal injury ... See more keywords
Alpha‐2‐macroglobulin in hemostasis and thrombosis: An underestimated old double‐edged sword
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15647
Abstract: Antiproteinases such as alpha‐2‐macroglobulin (A2M) play a role in hemostasis. A2M is highly conserved throughout evolution and is a high molecular weight homo‐tetrameric glycoprotein. A2M proteinase inhibitor activity is possible via a unique cage structure… read more here.
Keywords: hemostasis; a2m; hemostasis thrombosis; thrombosis ... See more keywords
Regenerative medicine for neuropathic pain: physiology, ultrasound and therapies with a focus on alpha-2-macroglobulin.
Sign Up to like & getrecommendations! Published in 2022 at "Pain management"
DOI: 10.2217/pmt-2022-0006
Abstract: The currently available drugs to treat neuropathic pain do not provide adequate pain management. As such, other treatments including stem cells, platelet-rich plasma and plasma-derived molecules such as alpha-2 macroglobulin (A2M) are being explored because… read more here.
Keywords: regenerative medicine; physiology; neuropathic pain; medicine ... See more keywords
Alpha-2-Macroglobulin in Inflammation, Immunity and Infections
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.803244
Abstract: Alpha-2-macroglobulin is an extracellular macromolecule mainly known for its role as a broad-spectrum protease inhibitor. By presenting itself as an optimal substrate for endopeptidases of all catalytic types, alpha-2-macroglobulin lures active proteases into its molecular… read more here.
Keywords: immunity infections; inflammation immunity; alpha macroglobulin;
Novel heterozygous mutation in alpha-2-macroglobulin (A2M) suppressing the binding of amyloid-β (Aβ)
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.1090900
Abstract: Introduction Many studies have suggested that the alpha-2-macroglobulin (A2M) gene may be involved in the pathogenesis of Alzheimer's disease (AD). A2M encoded by the A2M gene can specifically bind to the β-amyloid peptide and prevent… read more here.
Keywords: a2m; analysis; macroglobulin a2m; mutation ... See more keywords
Predictive Modeling of Thoracic Radiotherapy Toxicity and the Potential Role of Serum Alpha-2-Macroglobulin
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.01395
Abstract: Background: To investigate the impact of alpha-2-macroglobulin (A2M), a suspected intrinsic radioprotectant, on radiation pneumonitis and esophagitis using multifactorial predictive models. Materials and Methods: Baseline A2M levels were obtained for 258 patients prior to thoracic… read more here.
Keywords: thoracic radiotherapy; baseline a2m; a2m; alpha macroglobulin ... See more keywords
Activated Alpha-2 Macroglobulin Improves Insulin Response via LRP1 in Lipid-Loaded HL-1 Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22136915
Abstract: Activated alpha-2 Macroglobulin (α2M*) is specifically recognized by the cluster I/II of LRP1 (Low-density lipoprotein Receptor-related Protein-1). LRP1 is a scaffold protein for insulin receptor involved in the insulin-induced glucose transporter type 4 (GLUT4) translocation… read more here.
Keywords: activated alpha; response; insulin response; alpha macroglobulin ... See more keywords